Neuroradiology

, Volume 52, Issue 8, pp 759–765

Correlation of quantitative sensorimotor tractography with clinical grade of cerebral palsy

  • Richa Trivedi
  • Shruti Agarwal
  • Vipul Shah
  • Puneet Goyel
  • Vimal K. Paliwal
  • Ram K. S. Rathore
  • Rakesh K. Gupta
Paediatric Neuroradiology

DOI: 10.1007/s00234-010-0703-8

Cite this article as:
Trivedi, R., Agarwal, S., Shah, V. et al. Neuroradiology (2010) 52: 759. doi:10.1007/s00234-010-0703-8

Abstract

Introduction

The purpose of this study was to determine whether tract-specific diffusion tensor imaging measures in somatosensory and motor pathways correlate with clinical grades as defined using the Gross Motor Function Classification System (GMFCS) in cerebral palsy (CP) children.

Methods

Quantitative diffusion tensor tractography was performed on 39 patients with spastic quadriparesis (mean age = 8 years) and 14 age/sex-matched controls. All patients were graded on the basis of GMFCS scale into grade II (n = 12), grade IV (n = 22), and grade V (n = 5) CP and quantitative analysis reconstruction of somatosensory and motor tracts performed.

Results

Significant inverse correlation between clinical grade and fractional anisotropy (FA) was observed in both right and left motor and sensory tracts. A significant direct correlation of mean diffusivity values from both motor and sensory tracts was also observed with clinical grades. Successive decrease in FA values was observed in all tracts except for left motor tracts moving from age/sex-matched controls to grade V through grades II and IV.

Conclusion

We conclude that white matter tracts from both the somatosensory and the motor cortex play an important role in the pathophysiology of motor disability in patients with CP.

Keywords

Cerebral palsyDiffusion tensor imagingDiffusion tensor tractographyMotor pathwaySensory pathway

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Richa Trivedi
    • 1
  • Shruti Agarwal
    • 2
  • Vipul Shah
    • 3
  • Puneet Goyel
    • 4
  • Vimal K. Paliwal
    • 5
  • Ram K. S. Rathore
    • 2
  • Rakesh K. Gupta
    • 1
  1. 1.Department of RadiodiagnosisSanjay Gandhi Postgraduate Institute of Medical SciencesLucknowIndia
  2. 2.Department of Mathematics and StatisticsIndian Institute of TechnologyKanpurIndia
  3. 3.Pediatric Orthopedic Surgery unitBhargava Nursing HomeLucknowIndia
  4. 4.Department of AnesthesiologySanjay Gandhi Postgraduate Institute of Medical SciencesLucknowIndia
  5. 5.Department of NeurologySanjay Gandhi Postgraduate Institute of Medical SciencesLucknowIndia