Abstract
Based on the proposed higher order gradient quasi-continuum model, the numerical investigations of the basic mechanical properties and deformation behaviors of human red blood cell (RBC) membrane under large deformation at room temperature (i.e., 300 K) are carried out in the present paper. The results show that RBC membrane is a nonlinear hyperelastic material. The mechanical properties of RBC membrane is dominated by isotropic nature at the stage of initial deformation, however, its anisotropic material properties emerge clearly with the loading increasing. The out-of-plane wrinkling of RBC membrane upon shear loading can be reproduced numerically. With the use of the so-called higher order Cauchy–Born rule as the kinematic description, the bending stiffness of RBC membrane can be considered conveniently.
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The financial support from the Promotive Research Fund for Excellent Young and Middle-aged Scientists of Shandong Province, China (BS2014SF004), the Doctoral Starting up Foundation of Ludong University, China (LY2014022), the National Science Foundation of China (11372281), the province Science Foundation of Zhejiang (Y13A020009), and Natural Science Fund of Shandong Province (ZR2013EEL007) are gratefully acknowledged.
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Wang, X.Y., Wang, J.B., Qiu, B.B. et al. Large Deformation Properties of Red Blood Cell Membrane Based on a Higher Order Gradient Quasi-continuum Model. J Membrane Biol 248, 979–990 (2015). https://doi.org/10.1007/s00232-015-9809-6
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DOI: https://doi.org/10.1007/s00232-015-9809-6