References
D’Arcy DM, Casey E, Gowing CM, Donnelly MB, Corrigan OI (2012) An open prospective study of amikacin pharmacokinetics in critically ill patients during treatment with continuous venovenous haemodiafiltration. BMC Pharmacol Toxicol 13:14. doi:10.1186/2050-6511-13-14
Petejova N, Zahalkova J, Duricova J, Kacirova I, Brozmanova H, Urbanek K, Grundmann M, Martinek A (2012) Gentamicin pharmacokinetics during continuous venovenous hemofiltration in critically ill septic patients. J Chemother 24(2):107–112
Winter ME (2010) Basic clinical pharmacokinetics. Lippincott Williams and Wilkins, Philadelphia
Goncalves-Pereira J, Martins A, Povoa P (2010) Pharmacokinetics of gentamicin in critically ill patients: pilot study evaluating the first dose. Clin Microbiol Infect 26:1258–1263
Roberts JA, Lipman J (2006) Antibacterial dosing in intensive care. Clin Pharmacokinet 45(8):755–773
Fernández de Gatta MM, Martin-Suarez A, Lanao JM (2013) Approaches for dosage individualisation in critically ill patients. Expert Opin Drug Metab Toxicol 9(11):1481–1493
de Montmollin E, Bouadma L, Gault N, Mourvillier B, Mariotte E, Chemam S, Massias L, Papy E, Tubach F, Wolff M, Sonneville R (2014) Predictors of insufficient amikacin peak concentration in critically ill patients receiving a 25 mg/kg total body weight regimen. Intensive Care Med 40:998–1005
Acknowledgments
The authors acknowledge the tireless commitment of the ICU nursing staff to data collection, ongoing research and patient care.
Conflict of interest
The authors declare that they have no conflict of interest.
Ethical approval
Ethical approval for this study was obtained from the Joint Hospitals Ethics Committees (St James Hospital/Adelaide and Meath Hospital Dublin, incorporating the National Children’s Hospital Ref. No. 041007/7704). Authorisation was obtained from the Irish Medicines Board. Written informed consent to participate and publish (predominantly consent by proxy) was obtained in compliance with the Helsinki Declaration.
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Supplementary Table 1
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Supplementary Table 3
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Supplementary Fig. 1
Multiple gentamicin concentrations in a dosage interval for seven patients treated concurrently with gentamicin and CVVHDF therapy. ■ patient 1, □ patient 2, ▲ patient 3, ∆ patient 4, ● patient 5, ○ patient 6, × patient 7 (GIF 80.9 kb)
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D’Arcy, D.M., Corrigan, O.I., Deasy, E. et al. Gentamicin pharmacokinetics in critically ill patients during treatment with continuous venovenous haemodiafiltration (CVVHDF). Eur J Clin Pharmacol 71, 377–378 (2015). https://doi.org/10.1007/s00228-014-1765-z
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DOI: https://doi.org/10.1007/s00228-014-1765-z