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Serum Sclerostin Increases After Acute Physical Activity

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Abstract

Physical activity has a major impact on bone density and on osteoporosis prevention. Sclerostin is produced by osteocytes and inhibits bone formation. The impact of exercise on sclerostin secretion has not been studied so far. This pilot study aimed to explore circulating sclerostin levels immediately after acute exercise. Healthy young women practicing physical activity less than 120 min per week were enrolled. The exercise was a 45-min, low-speed, treadmill running test. Blood samples were taken at rest before exercise and within 5 min after the end of exercise. We assessed serum creatinine, 25-OH vitamin D, alkaline phosphatase, C-telopeptide of type I collagen, bone-specific alkaline phosphatase, and sclerostin. Sclerostin stability at rest was also validated over the same period of time among women fulfilling the same inclusion criteria. The study included 23 participants (mean ± SD age: 22.9 ± 1.5 years) for the exercise test and 9 participants for the resting test (26.1 ± 3.1 years). There was no difference in body mass index between the two groups. Sclerostin increased after exercise in comparison to baseline (mean ± SEM: 410 ± 27 vs. 290 ± 19 pg/mL; p < 0.001) corresponding to an increase of +44.3 ±5.5%. In the resting test, sclerostin remained stable (303 ± 20 vs. 294 ± 20 pg/mL, p = 0.76). There was a substantial increase in serum sclerostin in untrained healthy young women immediately after physical activity. These results suggest the existence of an acute release of systemic sclerostin in response to physical activity.

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Acknowledgements

The study received a research Grant from Roche-Chugai. The authors thank Georges Boivin, Eric Bomel, Céline Coutisson, Catherine Planckaert, Nathalie Rech, Philip Robinson, Agnès Rosay, Nadège Trehet-Mendel, and Cédric Trolliet for technical assistance. The authors also thank Genae Fitness Center, Bron, France for welcoming the venue and running machines, as well as all participants.

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Authors and Affiliations

  1. University of Lyon - INSERM UMR1033, 69003, Lyon, France

    Marie-Eva Pickering, Elisabeth Sornay-Rendu, Pawel Szulc & Cyrille B. Confavreux

  2. Department of Rheumatology, Hospices Civils de Lyon, 69003, Lyon, France

    Marie-Eva Pickering, Elisabeth Sornay-Rendu, Anne-Lise Raby & Cyrille B. Confavreux

  3. Medical Intensive Care Unit, Hospices Civils de Lyon, 69003, Lyon, France

    Marie Simon

  4. Department of Biochemistry, Hospices Civils de Lyon, 69003, Lyon, France

    Karim Chikh & Marie-Christine Carlier

  5. INSERM UMR 1033, Faculté RTH Laënnec, 8 rue Guillaume Paradin, 69372, Lyon Cedex 08, France

    Cyrille B. Confavreux

Authors
  1. Marie-Eva Pickering
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  2. Marie Simon
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  3. Elisabeth Sornay-Rendu
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  4. Karim Chikh
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  5. Marie-Christine Carlier
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  6. Anne-Lise Raby
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  7. Pawel Szulc
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  8. Cyrille B. Confavreux
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Corresponding author

Correspondence to Cyrille B. Confavreux.

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Conflict of interest

Marie-Eva Pickering, Marie Simon, Elisabeth Sornay-Rendu, Karim Chikh, Marie-Christine Carlier, Anne-Lise Raby, Pawel Szulc, and Cyrille B. Confavreux state they have no conflict of interest for this study.

Human and Animal Rights

The study was reviewed and approved by our local institutional ethics committee. The protocol followed standardized ethical and safety good clinical practice guidelines, and procedures were in accordance with the declaration of Helsinki.

Informed Consent

Eligible volunteers were informed about the protocol and provided a signed informed consent before undergoing a medical interview and the exercise test.

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Pickering, ME., Simon, M., Sornay-Rendu, E. et al. Serum Sclerostin Increases After Acute Physical Activity. Calcif Tissue Int 101, 170–173 (2017). https://doi.org/10.1007/s00223-017-0272-5

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  • DOI: https://doi.org/10.1007/s00223-017-0272-5

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