Original Research

Calcified Tissue International

, Volume 92, Issue 2, pp 207-215

Prevention and Treatment of Vitamin D Deficiency

  • Akash SinhaAffiliated withInstitute of Genetic Medicine, Newcastle University, International Centre for LifePaediatric Endocrinology, Royal Victoria Infirmary
  • , Tim D. CheethamAffiliated withInstitute of Genetic Medicine, Newcastle University, International Centre for LifePaediatric Endocrinology, Royal Victoria Infirmary
  • , Simon H. S. PearceAffiliated withInstitute of Genetic Medicine, Newcastle University, International Centre for LifeEndocrinology, Royal Victoria Infirmary Email author 

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Abstract

Vitamin D insufficiency and deficiency are widespread in many countries. We review the evidence pertaining to its prevention and treatment. Deficiency may be adequately treated with many different therapeutic regimens of either cholecalciferol or ergocalciferol, owing to the high therapeutic index of both compounds. Nevertheless, the current evidence suggests that regular dosing with oral cholecalciferol (e.g., 60,000 IU weekly) may have slight advantages over other regimens when replenishing vitamin D stores following deficiency. For long-term supplementation, smaller regular doses, such as cholecalciferol 1,000 IU daily, or 10,000 IU weekly, are suitable. Giving reliable and specific advice about appropriate sunlight exposure remains difficult because of differing interindividual skin pigmentation and variable sunlight UVB content at different latitudes, at different times of year, and in different terrestrial environments.

Keywords

Vitamin D Rickets Osteomalacia