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Serotonergic modulation of hippocampal theta activity in relation to hippocampal information processing

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Abstract

Hippocampal theta activity is the result of the concerted activity of a group of nuclei located in the brain stem and the caudal diencephalic area, which are together referred to as the synchronizing ascending system. Serotonin is recognized as the only neurotransmitter able to desynchronize the hippocampal electroencephalographic. A theory has been developed in which serotonin, acting on medial septal neurons, modulates cholinergic/GABAergic inputs to the hippocampus and, thus, the cognitive processing mediated by this area. However, few studies have addressed the relationship between serotonin modulation of theta activity and cognition. In this review, we present a summary and analysis of the data relating serotonin and its theta activity modulation with cognition, and we also discuss the few works relating serotonin, theta activity and cognition as well as the theories regarding the serotonin regulation of memory processes organized by the hippocampus. We propose that serotonin depletion induces impairment of the relays coding the frequency of hippocampal theta activity, whereas depletion of the relays in which frequency is not coded induces improvements in spatial learning that are related to increased expression of high-frequency theta activity.

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Acknowledgments

This work was supported by the Consejo Nacional de Ciencia y Tecnología no. CB-2010-01 and no. CB-2010-01/150959.

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  1. Laboratorio de Neurofisiología Experimental, Centro de Investigación Biomédica de Michoacán, Instituto Mexicano del Seguro Social, Morelia, México

    María Esther Olvera-Cortés, Blanca Erika Gutiérrez-Guzmán & J. Jesús Hernández-Pérez

  2. Laboratorio de Biofísica, Instituto de Física y Matemáticas, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, México

    Elisa López-Loeza & Miguel Ángel López-Vázquez

  3. Laboratorio de Neuroplasticidad de los Procesos Cognoscitivos, Centro de Investigación Biomédica de Michoacán, Instituto Mexicano del Seguro Social, Morelia, México

    Miguel Ángel López-Vázquez

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Olvera-Cortés, M.E., Gutiérrez-Guzmán, B.E., López-Loeza, E. et al. Serotonergic modulation of hippocampal theta activity in relation to hippocampal information processing. Exp Brain Res 230, 407–426 (2013). https://doi.org/10.1007/s00221-013-3679-x

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