Original Paper

European Food Research and Technology

, Volume 227, Issue 6, pp 1641-1650

Influence of grape variety and their phenolic composition on vasorelaxing activity of young red wines

  • Teresa OrtegaAffiliated withDepartamento de Farmacología, Facultad de Farmacia, Universidad Complutense de Madrid Email author 
  • , Elena De La HeraAffiliated withDepartamento de Farmacología, Facultad de Farmacia, Universidad Complutense de Madrid
  • , M. Emilia CarreteroAffiliated withDepartamento de Farmacología, Facultad de Farmacia, Universidad Complutense de Madrid
  • , Pilar Gómez-SerranillosAffiliated withDepartamento de Farmacología, Facultad de Farmacia, Universidad Complutense de Madrid
  • , M. Victoria NavalAffiliated withDepartamento de Farmacología, Facultad de Farmacia, Universidad Complutense de Madrid
  • , Angel M. VillarAffiliated withDepartamento de Farmacología, Facultad de Farmacia, Universidad Complutense de Madrid
  • , Marin ProdanovAffiliated withDepartamento de Agroalimentación, Instituto Madrileño de Investigación y Desarrollo Rural
  • , Visitación VacasAffiliated withDepartamento de Agroalimentación, Instituto Madrileño de Investigación y Desarrollo Rural
  • , Teresa ArroyoAffiliated withDepartamento de Agroalimentación, Instituto Madrileño de Investigación y Desarrollo Rural
    • , Teresa HernándezAffiliated withInstituto de Fermentaciones Industriales
    • , Isabel EstrellaAffiliated withInstituto de Fermentaciones Industriales

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Abstract

Red wine has been reported to exert beneficial effects in preventing cardiovascular diseases probably due to their polyphenols constituents. The vasorelaxant capacity and phenolic composition of four monovarietal young red wines Merlot, Tempranillo, Garnacha and Cabernet-Sauvignon obtained from grapes from 2004 vintage, cultivated under the same climatic and agricultural conditions, wine-making technology and storage conditions, were determined using vascular reactivity assay in rat aortic and high-performance liquid chromatography, respectively. Primary cultures of vascular smooth muscle cells from Wistar rats were also used to evaluate their survival prevention activity as well. Every studied wine present vasorelaxation effect, but the higher value corresponds to the analyzed Merlot wine, especially rich in phenolic compounds, mainly catechins and oligomeric proanthocyanidins and anthocyanin glycosides. This study further demonstrated previous investigations about the phenolic composition of wines relation with their vasorelaxation activity.

Keywords

Young monovarietal wine Merlot Tempranillo Garnacha Cabernet-Sauvignon Phenolic composition Vasorelaxation Vasoprotective