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Influence of grape variety and their phenolic composition on vasorelaxing activity of young red wines

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Abstract

Red wine has been reported to exert beneficial effects in preventing cardiovascular diseases probably due to their polyphenols constituents. The vasorelaxant capacity and phenolic composition of four monovarietal young red wines Merlot, Tempranillo, Garnacha and Cabernet-Sauvignon obtained from grapes from 2004 vintage, cultivated under the same climatic and agricultural conditions, wine-making technology and storage conditions, were determined using vascular reactivity assay in rat aortic and high-performance liquid chromatography, respectively. Primary cultures of vascular smooth muscle cells from Wistar rats were also used to evaluate their survival prevention activity as well. Every studied wine present vasorelaxation effect, but the higher value corresponds to the analyzed Merlot wine, especially rich in phenolic compounds, mainly catechins and oligomeric proanthocyanidins and anthocyanin glycosides. This study further demonstrated previous investigations about the phenolic composition of wines relation with their vasorelaxation activity.

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Acknowledgments

This project was supported by the Spanish Ministry of Science and Technology and the National Institute of Investigation in Agricultural and Alimentation Technology INIA (VIN03-009-C2-2). The authors thank Luis Piñal for his technical assistance.

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Authors and Affiliations

  1. Departamento de Farmacología, Facultad de Farmacia, Universidad Complutense de Madrid, 28040, Madrid, Spain

    Teresa Ortega, Elena De La Hera, M. Emilia Carretero, Pilar Gómez-Serranillos, M. Victoria Naval & Angel M. Villar

  2. Departamento de Agroalimentación, Instituto Madrileño de Investigación y Desarrollo Rural, Agrario y Alimentario, Ctra, A-2, km 38.2, 28800, Alcalá de Henares, Madrid, Spain

    Marin Prodanov, Visitación Vacas & Teresa Arroyo

  3. Instituto de Fermentaciones Industriales, CSIC. C/ Juan de la Cierva, 3, 28006, Madrid, Spain

    Teresa Hernández & Isabel Estrella

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  1. Teresa Ortega
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  2. Elena De La Hera
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  3. M. Emilia Carretero
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Correspondence to Teresa Ortega.

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Ortega, T., De La Hera, E., Carretero, M.E. et al. Influence of grape variety and their phenolic composition on vasorelaxing activity of young red wines. Eur Food Res Technol 227, 1641–1650 (2008). https://doi.org/10.1007/s00217-008-0888-9

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  • DOI: https://doi.org/10.1007/s00217-008-0888-9

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