Analytical and Bioanalytical Chemistry

, Volume 396, Issue 1, pp 339–364

Recent developments and applications of microextraction techniques in drug analysis

Review

DOI: 10.1007/s00216-009-3076-2

Cite this article as:
Kataoka, H. Anal Bioanal Chem (2010) 396: 339. doi:10.1007/s00216-009-3076-2

Abstract

Sample preparation is important for isolating desired components from complex matrices and greatly influences their reliable and accurate analysis. Recent trends in sample preparation include miniaturization, automation, high-throughput performance, online coupling with analytical instruments, and low-cost operation through extremely low or no solvent consumption. Microextraction techniques, such as liquid-phase microextraction and solid-phase microextraction, have these advantages over the traditional approaches of liquid–liquid extraction and conventional solid-phase extraction. This review focuses primarily on these microextraction techniques developed over the last decade, and presents a summary of the characteristics of various approaches in drug analysis.

Keywords

Sample preparationLiquid-phase microextractionSingle-drop microextractionSolid-phase microextractionIn-tube solid-phase microextractionDrug analysis

Abbreviations

ADS

alkyl diol silica

CE

capillary electrophoresis

DI

direct immersion

DVB

divinylbenzene

FNME

fiber-packed-needle microextraction

GC

gas chromatography

HF

hollow fiber

HPLC

high-performance liquid chromatography

HS

headspace

LC

liquid chromatography

LLE

liquid–liquid extraction

LPME

liquid-phase microextraction

MEPS

microextraction in a packed syringe

MIP

molecularly imprinted polymer

MS

mass spectrometry

PDMS

poly(dimethylsiloxane)

PEEK

polyetheretherketone

PPY

polypyrrole

PVDF

poly(vinylidene fluoride)

RAM

restricted access material

SBSE

stir-bar sorptive extraction

SDME

single-drop microextraction

SPDE

solid-phase dynamic extraction

SPE

solid-phase extraction

SPME

solid-phase microextraction

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  1. 1.School of PharmacyShujitsu UniversityNishigawara, OkayamaJapan