Special Issue Paper

Analytical and Bioanalytical Chemistry

, Volume 373, Issue 7, pp 571-586

Small molecule analysis by MALDI mass spectrometry

  • Lucinda H. CohenAffiliated withPfizer Global Research and Development, Bioanalytical Research, Department of Pharmacokinetics, Dynamics & Metabolism, 2800 Plymouth Road, Ann Arbor, MI 48105
  • , Arkady I. GusevAffiliated withPfizer Global Research and Development, Bioanalytical Research, Department of Pharmacokinetics, Dynamics & Metabolism, 2800 Plymouth Road, Ann Arbor, MI 48105

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Abstract

This review focuses on the application of matrix assisted laser desorption/ionization (MALDI) mass spectrometry to the characterization of molecules in the low mass range (<1500 Da). Despite its reputation to the contrary, MALDI is a powerful technique to provide both qualitative and quantitative determination of low molecular weight compounds. Several approaches to minimize interference via sample preparation and matrix selection are discussed, as well as coupling of MALDI to liquid and planar chromatographic techniques to extend its range of applicability.

MALDI MS Mass spectrometry Low molecular weight compounds