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Neuronal effects of nicotine during auditory selective attention

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Abstract

Rationale

Although the attention-enhancing effects of nicotine have been behaviorally and neurophysiologically well-documented, its localized functional effects during selective attention are poorly understood.

Objectives

In this study, we examined the neuronal effects of nicotine during auditory selective attention in healthy human nonsmokers. We hypothesized to observe significant effects of nicotine in attention-associated brain areas, driven by nicotine-induced increases in activity as a function of increasing task demands.

Methods

A single-blind, prospective, randomized crossover design was used to examine neuronal response associated with a go/no-go task after 7 mg nicotine or placebo patch administration in 20 individuals who underwent functional magnetic resonance imaging at 3T. The task design included two levels of difficulty (ordered vs. random stimuli) and two levels of auditory distraction (silence vs. noise).

Results

Significant treatment × difficulty × distraction interaction effects on neuronal response were observed in the hippocampus, ventral parietal cortex, and anterior cingulate. In contrast to our hypothesis, U and inverted U-shaped dependencies were observed between the effects of nicotine on response and task demands, depending on the brain area.

Conclusions

These results suggest that nicotine may differentially affect neuronal response depending on task conditions. These results have important theoretical implications for understanding how cholinergic tone may influence the neurobiology of selective attention.

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Acknowledgments

The authors thank Debra Singel for assistance with data acquisition. This work was supported by NIMH Conte Center Grant MH-086383, the VA Biomedical Laboratory and Clinical Science Research and Development Service, the Brain and Behavior Foundation, and the Blowitz-Ridgeway Foundation.

Conflict of interest

The authors declare no conflicts of interest.

Author information

Authors and Affiliations

  1. Research Service, Denver VA Medical Center, Denver, CO, USA

    Jason Smucny, Ann Olincy & Jason R. Tregellas

  2. Department of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora, CO, USA

    Jason Smucny, Ann Olincy, Lindsay S. Eichman & Jason R. Tregellas

  3. Neuroscience Program, University of Colorado Anschutz Medical Campus, Aurora, CO, USA

    Jason Smucny & Jason R. Tregellas

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  1. Jason Smucny
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  2. Ann Olincy
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Correspondence to Jason Smucny.

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Smucny, J., Olincy, A., Eichman, L.S. et al. Neuronal effects of nicotine during auditory selective attention. Psychopharmacology 232, 2017–2028 (2015). https://doi.org/10.1007/s00213-014-3832-7

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  • DOI: https://doi.org/10.1007/s00213-014-3832-7

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