Green tea extract enhances parieto-frontal connectivity during working memory processing
- André SchmidtAffiliated withDepartment of Psychiatry (UPK), University of BaselMedical Image Analysis Center
- , Felix HammannAffiliated withDepartment of Gastroenterology, University Hospital Basel
- , Bettina WölnerhanssenAffiliated withDepartment of Gastroenterology, University Hospital Basel
- , Anne Christin Meyer-GerspachAffiliated withDepartment of Gastroenterology, University Hospital Basel
- , Jürgen DreweAffiliated withDepartment of Gastroenterology, University Hospital Basel
- , Christoph BeglingerAffiliated withDepartment of Gastroenterology, University Hospital Basel
- , Stefan BorgwardtAffiliated withDepartment of Psychiatry (UPK), University of BaselMedical Image Analysis CenterDepartment of Psychosis Studies, Institute of Psychiatry, King’s College London Email author
It has been proposed that green tea extract may have a beneficial impact on cognitive functioning, suggesting promising clinical implications. However, the neural mechanisms underlying this putative cognitive enhancing effect of green tea extract still remain unknown.
This study investigates whether the intake of green tea extract modulates effective brain connectivity during working memory processing and whether connectivity parameters are related to task performance.
Material and methods
Using a double-blind, counterbalanced, within-subject design, 12 healthy volunteers received a milk whey-based soft drink containing 27.5 g of green tea extract or a milk whey-based soft drink without green tea as control substance while undergoing functional magnetic resonance imaging. Working memory effect on effective connectivity between frontal and parietal brain regions was evaluated using dynamic causal modeling.
Green tea extract increased the working memory induced modulation of connectivity from the right superior parietal lobule to the middle frontal gyrus. Notably, the magnitude of green tea induced increase in parieto-frontal connectivity positively correlated with improvement in task performance.
Our findings provide first evidence for the putative beneficial effect of green tea on cognitive functioning, in particular, on working memory processing at the neural system level by suggesting changes in short-term plasticity of parieto-frontal brain connections. Modeling effective connectivity among frontal and parietal brain regions during working memory processing might help to assess the efficacy of green tea for the treatment of cognitive impairments in psychiatric disorders such as dementia.
KeywordsCognition Working memory Green tea extract Brain activity Effective connectivity Dynamic causal modeling
- Green tea extract enhances parieto-frontal connectivity during working memory processing
- Open Access
- Available under Open Access This content is freely available online to anyone, anywhere at any time.
Volume 231, Issue 19 , pp 3879-3888
- Cover Date
- Print ISSN
- Online ISSN
- Springer Berlin Heidelberg
- Additional Links
- Working memory
- Green tea extract
- Brain activity
- Effective connectivity
- Dynamic causal modeling
- Industry Sectors
- Author Affiliations
- 1. Department of Psychiatry (UPK), University of Basel, Wilhelm Klein Str. 27, 4012, Basel, Switzerland
- 2. Medical Image Analysis Center, Schanzenstrasse 55, 4031, Basel, Switzerland
- 3. Department of Gastroenterology, University Hospital Basel, 4031, Basel, Switzerland
- 4. Department of Psychosis Studies, Institute of Psychiatry, King’s College London, London, UK