Psychopharmacology

, Volume 220, Issue 4, pp 751–762

Linking the pharmacological content of ecstasy tablets to the subjective experiences of drug users

Authors

    • Drug Information and Monitoring SystemNetherlands Institute of Mental Health and Addiction
    • Trimbos InstituteNetherlands Institute of Mental Health and Addiction
  • Maarten W. Koeter
    • Amsterdam Institute for Addiction ResearchAcademic Medical Center of the University of Amsterdam
  • Raymond J. M. Niesink
    • Drug Information and Monitoring SystemNetherlands Institute of Mental Health and Addiction
  • Wim van den Brink
    • Amsterdam Institute for Addiction ResearchAcademic Medical Center of the University of Amsterdam
Original Investigation

DOI: 10.1007/s00213-011-2529-4

Cite this article as:
Brunt, T.M., Koeter, M.W., Niesink, R.J.M. et al. Psychopharmacology (2012) 220: 751. doi:10.1007/s00213-011-2529-4

Abstract

Rationale

Most studies on the subjective effects of ecstasy are based on the assumption that the substance that was taken is 3,4-methylenedioxymethamphetamine (MDMA). However, many tablets sold as ecstasy contain other substances and MDMA in varying doses. So far, few attempts have been made to take this into account while assessing subjective effects.

Objectives

This study aims to link the pharmacological content of tablets sold as ecstasy to the subjective experiences reported by ecstasy users.

Methods

Self-reported effects on ecstasy tablets were available from 5,786 drug users who handed in their tablets for chemical analysis at the Drug Information and Monitoring System (DIMS) in the Netherlands. Logistic regression was employed to link the pharmacological content of ecstasy tablets to the self-reported subjective effects and compare effects with MDMA to other substances present.

Results

MDMA showed a strong association with desirable subjective effects, unparalleled by any other psychoactive substance. However, the association of MDMA was dose-dependent, with higher doses (>120 mg/tablet) likely to evoke more adverse effects. The novel psychostimulants mephedrone and p-fluoroamphetamine were considered relatively desirable, whereas meta-chlorophenylpiperazine (mCPP) and p-methoxymethamphetamine (PMMA) were strongly associated with adverse subjective effects. Also, 3,4-methylene-dioxyamphetamine (MDA) and benzylpiperazine (BZP) were not appreciated as replacement for MDMA.

Conclusion

Linking the pharmacological content of ecstasy sold on the street to subjective experiences contributes to a better understanding of the wide range of subjective effects ascribed to ecstasy and provides a strong rationale for the prolonged endurance of MDMA as the key ingredient of the ecstasy market.

Keywords

3,4-Methylenedioxymethamphetamine (MDMA) Ecstasy Subjective effects Desirable Adverse Dose

Copyright information

© Springer-Verlag 2011