Psychopharmacology

, Volume 214, Issue 1, pp 121–130

Early-life stress and cognitive outcome

Authors

    • 1001 SWKT, Department of PsychologyBrigham Young University
    • The Neuroscience CenterBrigham Young University
  • Fu Lye Woon
    • Neuropsychology Section, Department of PsychiatryUniversity of Michigan
Review

DOI: 10.1007/s00213-010-2090-6

Cite this article as:
Hedges, D.W. & Woon, F.L. Psychopharmacology (2011) 214: 121. doi:10.1007/s00213-010-2090-6

Abstract

Rationale

Early-life stress is associated with later neuropsychiatric illness. While the association between early-life stress and brain development is well recognized, relatively few studies have examined the association between exposure to early-life stress and cognitive outcome.

Objectives

The objective of this paper is to examine the association between early-life stress and cognitive outcome in animal models and humans.

Methods

In this article, we review alterations in cognitive function associated with early-life stress in animals and then discuss the association of early-life stress and cognitive function in humans.

Results

Findings suggest that early-life stress is associated with abnormal cognitive function in animals and humans. Furthermore, cognitive deficits associated with exposure to early-life stress in humans may persist into at least early adulthood, although animal models of enriched environments and studies of children adopted from institutionalized care into foster families suggest that certain social factors may at least partially reverse cognitive deficits following exposure to early-life stress.

Conclusions

Exposure to stress in early life may be associated with later deficits in cognitive function.

Keywords

Early-life stress Cognition Cognitive function Memory Childhood abuse Neglect Posttraumatic-stress disorder Hippocampus Neuropsychology

Copyright information

© Springer-Verlag 2010