Serotonin transporter binding after recovery from eating disorders
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Several lines of evidence suggest that altered serotonin (5-HT) function persists after recovery from anorexia nervosa (AN) and bulimia nervosa (BN).
We compared 11 subjects who recovered (>1 year normal weight, regular menstrual cycles, no bingeing or purging) from restricting-type AN (REC RAN), 7 who recovered from bulimia-type AN (REC BAN), 9 who recovered from BN (REC BN), and 10 healthy control women (CW).
Materials and methods
Positron emission tomography (PET) imaging with [11C]McN5652 was used to assess the 5-HT transporter (5-HTT). For [11C]McN5652, distribution volume (DV) values were determined using a two-compartment, three-parameter tracer kinetic model, and specific binding was assessed using the binding potential (BP, BP = DVregion of interest/DVcerebellum − 1).
After correction for multiple comparisons, the four groups showed significant (p < 0.05) differences for [11C]McN5652 BP values for the dorsal raphe and antero-ventral striatum (AVS). Post-hoc analysis revealed that REC RAN had significantly increased [11C]McN5652 BP compared to REC BAN in these regions.
Divergent 5-HTT activity in subtypes of eating disorder subjects may provide important insights as to why these groups have differences in affective regulation and impulse control.
- Serotonin transporter binding after recovery from eating disorders
Volume 195, Issue 3 , pp 315-324
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- Anorexia nervosa
- Bulimia nervosa
- Serotonin transporter
- Positron emission tomography
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- Author Affiliations
- 1. Western Psychiatric Institute and Clinic, University of Pittsburgh, Iroquois Building, Suite 600, 3811 O’Hara Street, Pittsburgh, PA, 15213, USA
- 3. Department of Biological Psychiatry, University Hospital of Psychiatry, Medical University of Vienna, Vienna, Austria
- 7. Laboratory for Developmental Brain Research, University of Colorado at Denver and Health Sciences Center, The Children’s Hospital, 1056 E. 19th Avenue, Denver, CO, 80218, USA
- 4. Department of Radiology, Presbyterian University Hospital, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
- 5. Departments of Radiology and Neurology, Emory School of Medicine, Atlanta, GA, USA
- 6. School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
- 8. Department of Child and Adolescent Psychiatry, J.W. Goethe University of Frankfurt/Main, Frankfurt/Main, Germany
- 9. New York State Psychiatric Institute, Department of Psychiatry, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY, USA
- 10. Department of Environmental Health, Division of Epidemiology and Biostatistics, University of Cincinnati School of Medicine, Cincinnati, OH, USA
- 2. Psychiatry, University of California San Diego, 8950 Villa La Jolla Drive, Suite C207, La Jolla, CA, 92037, USA