Psychopharmacology

, Volume 191, Issue 3, pp 391–431

The debate over dopamine’s role in reward: the case for incentive salience

Review

DOI: 10.1007/s00213-006-0578-x

Cite this article as:
Berridge, K.C. Psychopharmacology (2007) 191: 391. doi:10.1007/s00213-006-0578-x

Abstract

Introduction

Debate continues over the precise causal contribution made by mesolimbic dopamine systems to reward. There are three competing explanatory categories: ‘liking’, learning, and ‘wanting’. Does dopamine mostly mediate the hedonic impact of reward (‘liking’)? Does it instead mediate learned predictions of future reward, prediction error teaching signals and stamp in associative links (learning)? Or does dopamine motivate the pursuit of rewards by attributing incentive salience to reward-related stimuli (‘wanting’)? Each hypothesis is evaluated here, and it is suggested that the incentive salience or ‘wanting’ hypothesis of dopamine function may be consistent with more evidence than either learning or ‘liking’. In brief, recent evidence indicates that dopamine is neither necessary nor sufficient to mediate changes in hedonic ‘liking’ for sensory pleasures. Other recent evidence indicates that dopamine is not needed for new learning, and not sufficient to directly mediate learning by causing teaching or prediction signals. By contrast, growing evidence indicates that dopamine does contribute causally to incentive salience. Dopamine appears necessary for normal ‘wanting’, and dopamine activation can be sufficient to enhance cue-triggered incentive salience. Drugs of abuse that promote dopamine signals short circuit and sensitize dynamic mesolimbic mechanisms that evolved to attribute incentive salience to rewards. Such drugs interact with incentive salience integrations of Pavlovian associative information with physiological state signals. That interaction sets the stage to cause compulsive ‘wanting’ in addiction, but also provides opportunities for experiments to disentangle ‘wanting’, ‘liking’, and learning hypotheses. Results from studies that exploited those opportunities are described here.

Conclusion

In short, dopamine’s contribution appears to be chiefly to cause ‘wanting’ for hedonic rewards, more than ‘liking’ or learning for those rewards.

Keywords

AccumbensRewardOpioidDopamineBasal forebrainAversionAssociative learningAppetiteAddiction

Supplementary material

213_2006_578_MOESM1_ESM.mpg (12.1 mb)
Movie 1Hedonic taste reactions. Examples of positive facial ‘liking’ reactions elicited by sweet taste of sucrose solution from newborn human infants (via oral dropper) and adult rats (via oral cannula). Negative ‘disliking’ reactions elicited by bitter taste of quinine solution. Human infant reactions from Steiner et al. (2001); Rat reactions from Berridge (2000) (MPG 12 mb)

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  1. 1.Department of PsychologyUniversity of MichiganAnn ArborUSA