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Dopamine receptor stimulation does not modulate the loudness dependence of the auditory evoked potential in humans

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Abstract

Rationale

The Loudness Dependence of the Auditory Evoked Potential (LDAEP) has been suggested as a reliable measure of central serotonin function in humans; however, its specificity for the serotonin system remains a topic of debate, with possible modulation of this purported serotonin marker by other neurotransmitters, including dopamine.

Objectives

We examined the effect of dopaminergic modulation on the LDAEP using the D1/D2/D3 dopamine receptor agonist pergolide and the D2/D3 agonist bromocriptine.

Methods

The study was a double-blind, placebo-controlled repeated-measures design in which healthy participants were tested under three acute treatment conditions: placebo, bromocriptine (2.5 mg), and pergolide (0.1 mg). Changes in the amplitude of the N1/P2 at intensities (60, 70, 80, 90, and 100 dB) were examined at C Z.

Results

Acute stimulation of D1/D2/D3 receptors with pergolide and D2/D3 receptors with bromocriptine in comparison with placebo had no effect on the LDAEP.

Conclusion

These findings indicate that acute stimulation of dopamine D1, D2, and D3 receptors does not modulate the LDAEP in humans. Although the findings suggest that the LDAEP may not be modulated by acute changes in dopamine neurotransmission, further studies are needed to fully characterize its dopaminergic sensitivity.

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Acknowledgement

The study was supported by a grant to P.J.N. from the National Health and Medical Research Council (NHMRC) of Australia (grant no. 345709). Participant medical examinations were conducted by Susan Illic, M.D.

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Authors and Affiliations

  1. Brain Sciences Institute, Swinburne University of Technology, Melbourne, Australia

    Barry V. O’Neill, Rodney J. Croft, Sumie Leung & Valérie Guille

  2. Department of Psychiatry and Behavioral Neuroscience, Wayne State University, Detroit, MI, USA

    Matthew Galloway

  3. Behavioural Neuroscience Laboratory, Department of Physiology, Monash Centre for Brain and Behaviour, Monash University, P.O.Box 13F, Victoria, 3800, Australia

    K. Luan Phan & Pradeep J. Nathan

  4. Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry, Biological Sciences Division, and the Pritzker School of Medicine, The University of Chicago, Chicago, IL, USA

    K. Luan Phan

Authors
  1. Barry V. O’Neill
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  2. Rodney J. Croft
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  4. Valérie Guille
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  6. K. Luan Phan
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  7. Pradeep J. Nathan
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Correspondence to Pradeep J. Nathan.

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O’Neill, B.V., Croft, R.J., Leung, S. et al. Dopamine receptor stimulation does not modulate the loudness dependence of the auditory evoked potential in humans. Psychopharmacology 188, 92–99 (2006). https://doi.org/10.1007/s00213-006-0501-5

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  • DOI: https://doi.org/10.1007/s00213-006-0501-5

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