Psychopharmacology

, Volume 160, Issue 1, pp 1–8

Long-term effects of neonatal MK-801 treatment on spatial learning and cortical plasticity in adult rats

Authors

  • Hajnalka Németh
    • Department of Comparative Physiology, University of Szeged, POB 533, 6701 Szeged, Hungary
  • Hedvig Varga
    • Department of Comparative Physiology, University of Szeged, POB 533, 6701 Szeged, Hungary
  • Tamás Farkas
    • Department of Comparative Physiology, University of Szeged, POB 533, 6701 Szeged, Hungary
  • Zsolt Kis
    • Department of Comparative Physiology, University of Szeged, POB 533, 6701 Szeged, Hungary
  • László Vécsei
    • Department of Neurology, University of Szeged, POB 71, 6701 Szeged, Hungary
  • Szatmár Horváth
    • Department of Comparative Physiology, University of Szeged, POB 533, 6701 Szeged, Hungary
  • Krisztina Boda
    • Department of Medical Informatics, University of Szeged, Korányi fasor 9, 6720 Szeged, Hungary
  • Joachim R. Wolff
    • Department of Anatomy, University of Göttingen, Kreuzbergring 36, 37075 Göttingen, Germany
  • József Toldi
    • Department of Comparative Physiology, University of Szeged, POB 533, 6701 Szeged, Hungary
Original Investigation

DOI: 10.1007/s00213-001-0957-2

Cite this article as:
Németh, H., Varga, H., Farkas, T. et al. Psychopharmacology (2002) 160: 1. doi:10.1007/s00213-001-0957-2

Abstract.

Rationale and objectives: The long-term effects of neonatal treatment with MK-801 on spatial learning and cortical plasticity were investigated in adult rats. Methods: Rat pups were injected twice daily with MK-801 (0.1 mg/kg) on postnatal days 7–19, participated in water maze testing between postnatal days 90 and 102, and were then studied electrophysiologically. Results: Treatment with MK-801 in such a low dose resulted in a very slight impairment of performance in the water maze task, but not in the visual cue response. Besides the slight learning impairment, the electrophysiological study revealed a reduction in the capacity for plasticity in the primary motor cortex of the treated animals, which was pronounced in the controls. Conclusion: The study demonstrates that even a slight impairment in learning and memory function may be accompanied by a cortical plasticity deficiency that is detectable electrophysiologically.

Spatial learning Water maze MK-801 NMDA receptor Cortical plasticity Evoked potential Primary motor cortex Disinhibition

Copyright information

© Springer-Verlag 2001