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Antiulcerogenic activity of Carica papaya seed in rats

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Abstract

The purpose of the present study was to evaluate the gastroprotective and healing effects of the methanolic extract of the seed of the papaya Carica papaya L. (MECP) in rats. Models of acute gastric ulcer induction by ethanol and indomethacin and of chronic ulcer by acetic acid were used. The gastric juice and mucus parameters were evaluated using the pylorus ligation model, and the involvement of sulfhydryl compounds (GSH) and nitric oxide in the gastroprotective effect was analyzed using the ethanol model. The toxicity was assessed through toxicity tests. No signs of toxicity were observed when the rats received a single dose of 2000 mg/kg of extract. The MECP in doses of 125, 250, and 500 mg/kg significantly reduced the gastric lesion with 56, 76, and 82 % inhibition, respectively, and a dose of 30 mg/kg lansoprazole showed 79 % inhibition in the ethanol model. MECP (125, 250, 500 mg/kg) and cimetidine (200 mg/kg) reduced the gastric lesion in the indomethacin model, with 62, 67, 81, and 85 % inhibition, respectively. The MECP (500 mg/kg) and cimetidine (200 mg/kg) treatments showed a reduction in ulcerative symptoms induced by acetic acid by 84 and 73 %, respectively. The antiulcerogenic activity seems to involve GSH because the inhibition dropped from 72 to 13 % in the presence of a GSH inhibitor. Moreover, the MECP showed systemic action, increasing the mucus production and decreasing gastric acidity. Treatments with MECP induce gastroprotection without signs of toxicity. This effect seems to involve sulfhydryl compounds, increased mucus, and reduced gastric acidity.

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Acknowledgments

We thank the National Counsel of Technological and Scientific Development (CNPq) for funding this research.

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Authors and Affiliations

  1. School of Health Sciences, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil

    Lorraine Aparecida Pinto & Viviane Carrasco

  2. School of Medicine, Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil

    Kátia Wolff Cordeiro

  3. Department of Pharmacy and Biochemistry, Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil

    Carlos Alexandre Carollo

  4. Chemistry Center, State University of Mato Grosso do Sul, Dourados, Mato Grosso do Sul, Brazil

    Cláudia Andréa Lima Cardoso

  5. School of Engineering, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil

    Eliana Janet Sanjinez Argadoña

  6. Biological and Health Sciences Center, Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil

    Karine de Cássia Freitas

  7. Centro de Ciências Biológicas e da Saúde, Universidade Federal do Mato Grosso do Sul, Cidade Universitária, caixa postal 549, Campo Grande, MS, 79070-900, Brazil

    Karine de Cássia Freitas

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  1. Lorraine Aparecida Pinto
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Pinto, L.A., Cordeiro, K.W., Carrasco, V. et al. Antiulcerogenic activity of Carica papaya seed in rats. Naunyn-Schmiedeberg's Arch Pharmacol 388, 305–317 (2015). https://doi.org/10.1007/s00210-014-1069-y

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