Skip to main content
Log in

Tissues cIMPly do not lie

  • Debate
  • Published:
Naunyn-Schmiedeberg's Archives of Pharmacology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  • Aley PK, Singh N, Brailoiu GC, Brailoiu E, Churchill GC (2013) Nicotinic acid adenine dinucleotide phosphate (NAADP) is a second messenger in muscarinic receptor-induced contraction of guinea pig trachea. J Biol Chem 288:10986–10993

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Bähre H, Danker KY, Stasch JP, Kaever V, Seifert R (2014) Nucleotidyl cyclase activity of soluble guanylyl cyclase in intact cells. Biochem Biophys Res Commun 443:1195–1199

    Article  PubMed  Google Scholar 

  • Behmanesh M, Sakumi K, Abolhassani N, Toyokuni S, Oka S, Ohnishi YN, Tsuchimoto D, Nakabeppu Y (2009) ITPase-deficient mice show growth retardation and die before weaning. Cell Death Differ 16:1315–1322

    Article  CAS  PubMed  Google Scholar 

  • Beste KY, Burhenne H, Kaever V, Stasch JP, Seifert R (2012) Nucleotidyl cyclase activity of soluble guanylyl cyclase α1β1. Biochem 51:194–204

  • Beste KY, Spangler CM, Burhenne H, Koch KW, Shen Y, Tang WJ, Kaever V, Seifert R (2013) Nucleotidyl cyclase activity of particulate guanylyl cyclase A: comparison with particulate guanylyl cyclases E and F, soluble guanylyl Cyclase and bacterial adenylyl cyclases CyaA and edema factor. PLoS ONE 8:e70223

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Chan CK, Mak J, Gao Y, Man RY, Vanhoutte PM (2011) Endothelium derived NO, but not cyclic GMP, is required for hypoxic augmentation in isolated porcine coronary arteries. Am J Physiol Heart Circ Physiol 301:H2313–H2321

    Article  CAS  PubMed  Google Scholar 

  • Chen Z, Zhang X, Ying L, Dou D, Li Y, Bai Y, Liu J, Liu L, Feng H, Yu X, Leung SWS,Vanhoutte PM, Gao Y (2014) Cyclic IMP-synthesized by sGC as a mediator of hypoxic contraction of coronary arteries. Am J Physiol Heart Circ Physiol doi:10.1152/ajpheart.00132.2014

  • De Mey JG, Vanhoutte PM (1983) Anoxia and endothelium-dependent reactivity of the canine femoral artery. J Physiol 335:65–74

    PubMed Central  PubMed  Google Scholar 

  • Dhanakoti S, Gao Y, Nguyen MQ, Raj JU (2000) Involvement of cGMP-dependent protein kinase in the relaxation of ovine pulmonary arteries to cGMP and cAMP. J Appl Physiol 88:1637–1642

    CAS  PubMed  Google Scholar 

  • Duong-Quy S, Bei Y, Liu Z, Dinh-Xuan AT (2013) Role of Rho-kinase and its inhibitors in pulmonary hypertension. Pharmacol Ther 137:352–364

    Article  CAS  PubMed  Google Scholar 

  • Ferguson DR, Price RH (1973) The production of cIMP by toad bladder, and its effects on transport of water and salt. FEBS Lett 34:207–212

    Article  CAS  PubMed  Google Scholar 

  • Follmann M, Griebenow N, Hahn MG, Hartung I, Mais FJ, Mittendorf J, Schäfer M, Schirok H, Stasch JP, Stoll F, Straub A (2013) The chemistry and biology of soluble guanylate cyclase stimulators and activators. Angew Chem Int Ed Engl 52:9442–9462

    Article  CAS  PubMed  Google Scholar 

  • Friebe A, Koesling D (2009) The function of NO-sensitive guanylyl cyclase: what we can learn from genetic mouse models. Nitric Oxide 21:149–156

    Article  CAS  PubMed  Google Scholar 

  • Gao Y, Portugal AD, Negash S, Zhou W, Longo LD, Raj JU (2007) Role of Rho kinases in PKG-mediated relaxation of pulmonary arteries of fetal lambs exposed to chronic high altitude hypoxia. Am J Physiol Lung Cell Mol Physiol 292:L678–L684

    Article  CAS  PubMed  Google Scholar 

  • Graeser T, Vanhoutte PM (1991) Hypoxic contraction of canine coronary arteries: role of endothelium and cGMP. Am J Physiol Heart Circ Physiol 261:H1769–H1777

    Google Scholar 

  • Gribble FM, Loussouarn G, Tucker SJ, Zhao C, Nichols CG, Ashcroft FM (2000) A novel method for measurement of submembrane ATP concentration. J Biol Chem 275:30046–30049

    Article  CAS  PubMed  Google Scholar 

  • Pearson PJ, Lin PJ, Schaff HV, Vanhoutte PM (1996) Augmented endothelium-dependent constriction to hypoxia early and late following reperfusion of the canine coronary artery. Clin Exp Pharmacol Physiol 23:634–641

    Article  CAS  PubMed  Google Scholar 

  • Reinecke D, Burhenne H, Sandner P, Kaever V, Seifert R (2011) Human cyclic nucleotide phosphodiesterases possess a much broader substrate-specificity than previously appreciated. FEBS Lett 585:3259–3262

    Article  CAS  PubMed  Google Scholar 

  • Rubanyi GM, Vanhoutte PM (1985) Hypoxia releases a vasoconstrictor substance from the canine vascular endothelium. J Physiol 364:45–56

    CAS  PubMed Central  PubMed  Google Scholar 

  • Sakumi K, Abolhassani N, Behmanesh M, Iyama T, Tsuchimoto D, Nakabeppu Y (2010) ITPA protein, an enzyme that eliminates deaminated purine nucleoside triphosphates in cells. Mutat Res 703:43–50

    Article  CAS  PubMed  Google Scholar 

  • Seifert R (2014) Is cIMP a second messenger with functions opposite to those of cGMP? Naunyn Schmiedebergs Arch Pharmacol, this issure.

  • Somlyo AP, Somlyo AV (2003) Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase. Physiol Rev 83:1325–1358

    CAS  PubMed  Google Scholar 

  • Sutherland EW, Robison GA, Butcher RW (1968) Some aspects of the biological role of adenosine 3’,5’-monophosphate (Cyclic AMP). Circulation 37:279–306

    Article  CAS  Google Scholar 

  • Waldman SA, Murad F (1987) Cyclic GMP synthesis and function. Pharmacol Rev 39:163–196

    CAS  PubMed  Google Scholar 

  • Werner K, Schwede F, Genieser HG, Geiger J, Butt E (2011) Quantification of cAMP and cGMP analogs in intact cells: pitfalls in enzyme immunoassays for cyclic nucleotides. Naunyn Schmiedebergs Arch Pharmacol 384:169–176

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Wolter S, Golombek M, Seifert R (2011) Differential activation of cAMP- and cGMP-dependent protein kinases by cyclic purine and pyrimidine nucleotides. Biochem Biophys Res Commun 415:563–566

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

This work was supported in part by National Natural Science Foundation of China Grants 81270341 and the Hong Kong Research Grant Council (University of Hong Kong- 777507 M).

Conflict of interest

No conflicts of interest, financial or otherwise, are declared by the author(s).

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Paul M. Vanhoutte.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Gao, Y., Vanhoutte, P.M. Tissues cIMPly do not lie. Naunyn-Schmiedeberg's Arch Pharmacol 387, 901–903 (2014). https://doi.org/10.1007/s00210-014-1022-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00210-014-1022-0

Navigation