How Hip and Whole-Body Bone Mineral Density Predict Hip Fracture in Elderly Women: The EPIDOS Prospective Study
- A. M. SchottAffiliated withINSERM U 403, Hôpital Edouard Herriot, Lyon
- , C. CormierAffiliated withService de Rhumatologie, Hopital Cochin, Paris
- , D. HansAffiliated withINSERM U 403, Hôpital Edouard Herriot, Lyon
- , F. FavierAffiliated withINSERM CJF 93-06, Montpellier
- , E. HausherrAffiliated withINSERM U149, Villejuif
- , P. Dargent-MolinaAffiliated withINSERM U149, Villejuif
- , P. D. DelmasAffiliated withINSERM U 403, Hôpital Edouard Herriot, Lyon
- , C. RibotAffiliated withService d'Endocrinologie, Hopital Purpan, Toulouse
- , J. L. SebertAffiliated withService de Rhumatologie, Hopital Nord, Amiens, France.
- and 3 more
- , G. BreartAffiliated withINSERM U149, Villejuif
- , P. J. MeunierAffiliated withINSERM U 403, Hôpital Edouard Herriot, Lyon
- , for the EPIDOS Group
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We conducted a population-based cohort study in 7598 white healthy women, aged 75 years and over, recruited from the voting lists. We measured at baseline bone mineral density (BMD g/cm2) of the proximal femur (neck, trochanter and Ward's triangle) and the whole body, as well as fat and lean body mass, by dual-energy X-ray absorptiometry (DXA). One hundred and fifty-four women underwent a hip fracture during an average 2 years follow-up. Each standard deviation decrease in BMD increased the risk of hip fracture adjusted for age, weight and centre by 1.9 (95% CL 1.5, 2.3) for the femoral neck, 2.6 times (2.0, 3.3) for the trochanter, 1.8 times (1.4, 2.2) for Ward's triangle, 1.6 times (1.2, 2.0) for the whole body, and 1.3 times (1.0, 1.5) for the fat mass. The areas under the receiver operating characteristic (ROC) curves were not significantly different between trochanter and femoral neck BMD, whereas ROC curves of femoral neck and trochanter BMD were significantly better than those for Ward's triangle and whole-body BMD.
emsp;Women who sustained an intertrochanteric fracture were older (84 ± 4.5 years) than women who had a cervical fracture (81 ± 4.5 years) and trochanter BMD seemed to be a stronger predictor of intertrochanteric ([RR = 4.5 (3.1, 6.5)] than cervical fractures ([RR = 1.8 (1.5, 2.3]).
emsp;In very elderly women aged 80 years and more, hip BMD was still a significant predictor of hip fracture but the relative risk was significantly lower than in women younger than 80 years.
emsp;In the 48% of women who had a femoral neck BMD T-score less than –2.5, the relative risk of hip fracture was increased by 3, and the unadjusted incidence of hip fracture was 16.4 per 1000 woman-years compared with 1.1 in the population with a femoral neck BMD T-score 5–1.
- How Hip and Whole-Body Bone Mineral Density Predict Hip Fracture in Elderly Women: The EPIDOS Prospective Study
Volume 8, Issue 3 , pp 247-254
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- Key words: Aging – Bone mineral density – Hip fracture – Osteoporosis – Prospective study
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- Author Affiliations
- A1. INSERM U 403, Hôpital Edouard Herriot, Lyon, FR
- A2. Service de Rhumatologie, Hopital Cochin, Paris, FR
- A3. INSERM CJF 93-06, Montpellier, FR
- A4. INSERM U149, Villejuif, FR
- A5. Service d'Endocrinologie, Hopital Purpan, Toulouse, FR
- A6. Service de Rhumatologie, Hopital Nord, Amiens, France., FR