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Epidemiology of fragility fractures in Sakaiminato, Japan: incidence, secular trends, and prognosis

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Abstract

Summary

We investigated the incidence of fragility fractures from 2010 to 2012 in Sakaiminato, Japan. The incidence rates of limb fractures in Sakaiminato were lower than in Caucasian populations but had increased relative to data obtained in Japan in the 1990s. Clinical vertebral fractures occurred at higher rates in Sakaiminato than in Caucasian populations.

Introduction

To elucidate the incidence and prognosis of fragility fractures in Sakaiminato, Japan.

Methods

A survey of all hip, distal radius, proximal humerus, and clinical vertebral fractures was performed from 2010 to 2012 in patients aged 50 or older in Sakaiminato city, Tottori prefecture, Japan. The age- and gender-specific incidence rates (per 100,000 person-years) were calculated based on the population of Sakaiminato city each year. The incidence rates of hip, distal radius, and proximal humerus fractures were compared with previous reports. We conducted a follow-up study assessing patients within 1 year following their initial treatment at two Sakaiminato hospitals.

Results

The age-adjusted incidence rates in population aged 50 years or older (per 100,000 person-years) of hip, distal radius, proximal humerus, and clinical vertebral fractures were, respectively, 217, 82, 26, and 412 in males and 567, 432, 96, and 1229 in females. Age-specific incidence rates of hip, distal radius, and proximal humerus fractures all increased since the 1990s. Our study also revealed that anti-osteoporotic pharmacotherapy was prescribed 1 year post-fracture at rates of 29, 20, 30, and 50 % for patients with hip, distal radius, proximal humerus, and clinical vertebral fractures, respectively.

Conclusions

The incidence rates of limb fractures in Sakaiminato were substantially lower than Caucasian populations in northern Europe but had increased relative to data obtained in Japan in the 1990s. Unlike upper and lower limb fractures, clinical vertebral fractures occurred at higher rates in our study population than in other Asian and North European countries.

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Acknowledgments

The authors sincerely acknowledge Dr. Kimiko Tsuda, Dr. Kazuomi Fujise, Dr. Yoichiro Watanabe, Dr. Mitsuru Takigawa, Dr. Kazushi Ichiba, Dr. Nin Yamamoto, Dr. Tatsuhiko Nakamura, Dr. Takeshi Minamizaki, Dr. Takeo Otsuki, and the staff of the hospitals in Sakaiminato and Yonago that participated in this study. The authors express their sincere appreciation to Dr. Mikizo Okamoto for his statistical help. The authors also acknowledge Ms. Ryoko Ikehara for her help in the analyses and secretarial assistance.

Conflicts of interest

Yasuto Tsukutani and Yasuyo Ito declare that they have no conflict of interest. Hiroshi Hagino and Hideki Nagashima have received consulting fees from Asahi Kasei Pharma Corp., Astellas Pharma Inc., Banyu Pharmaceutical Co. Ltd., Chugai Pharmaceutical Co. Ltd., Eisai Co. Ltd., Eli Lilly Japan K.K., Mitsubishi Tanabe Pharma Corp., Ono Pharmaceutical Co. Ltd., Pfizer Inc., Takeda Pharmaceutical Co. Ltd., and Teijin Pharma Ltd.

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Authors and Affiliations

  1. Department of Orthopedic Surgery, Faculty of Medicine, Tottori University, 36-1 Nishi-Cho, Yonago, Tottori, 683-8504, Japan

    Y. Tsukutani & H. Nagashima

  2. School of Health Science, Tottori University, Tottori, Japan

    H. Hagino

  3. Ome Keiyu Hospital, Tokyo, Japan

    Y. Ito

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  1. Y. Tsukutani
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  2. H. Hagino
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  4. H. Nagashima
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Correspondence to Y. Tsukutani.

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Tsukutani, Y., Hagino, H., Ito, Y. et al. Epidemiology of fragility fractures in Sakaiminato, Japan: incidence, secular trends, and prognosis. Osteoporos Int 26, 2249–2255 (2015). https://doi.org/10.1007/s00198-015-3124-z

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  • DOI: https://doi.org/10.1007/s00198-015-3124-z

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