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Local renin-angiotensin system is associated with bone mineral density of glucocorticoid-induced osteoporosis patients

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Abstract

Summary

The local renin-angiotensin system (RAS) is closely related to bone metabolism. However, it is unknown whether the local RAS is related to bone mineral density (BMD) in glucocorticoid-induced osteoporosis (GIOP). Here, we revealed that the two main characteristics of GIOP might inhibit bone formation and enhance bone resorption.

Introduction

The aim of this study is to assess the expression of the main RAS components in the trabecular bone of lumbar vertebrae in GIOP and analyze the relationship between the major RAS components and BMD.

Methods

We collected 96 inpatient cases of lumbar disc herniation from patients who underwent dual-energy X-ray absorptiometry examinations followed by surgical treatment in our hospital. Patients were divided into the GIOP group (n = 48) and control group (n = 48). The circulating and local expression levels of the main RAS components were examined. The correlation between the main RAS components and BMD was then analyzed.

Results

The mRNA expression of local bone angiotensin type 1 and 2 receptors (AT1R and AT2R, respectively) and RANKL was higher in the GIOP group compared with the control group (p < 0.001), but there was no difference in the circulating protein levels between groups (p > 0.05). Multiple logistic regression analysis revealed that AT1R and AT2R expression and the RANKL/OPG ratio in local bone were negatively associated with BMD (p < 0.001, odds ratio (OR) 1.236, 95 % confidence interval (CI) 1.207–1.333; p < 0.001, OR 1.971, 95 % CI 1.809–2.233; and p < 0.001, OR 1.676, 95 % CI 1.546–1.845, respectively).

Conclusion

This study provides evidence that the role of local RAS is related to BMD in GIOP patients, and suggests that local RAS might influence RANKL/OPG signaling to modulate bone metabolism.

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Acknowledgments

The authors would like to thank Xue Xia for his expertise and assistance in performing the blood collection and Wang Quanshen for his technical assistance. This study was funded by Innovation Fund of Huazhong University of Science and Technology (Item Number: 2013QN235) and National Natural Science Foundation of China (Project Number: 81403257, 81473492, 81102692 and 81072943).

Conflicts of interest

None.

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Authors and Affiliations

  1. Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China

    B. Shuai, Y. P. Yang, L. Shen, R. Zhu, X. J. Xu, C. Ma & L. Lv

  2. School of Chinese medicine, the University of Hong Kong, Pok Fu Lam, Hong Kong

    J. Zhao & J. H. Rong

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  1. B. Shuai
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  2. Y. P. Yang
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  3. L. Shen
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  4. R. Zhu
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  5. X. J. Xu
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  6. C. Ma
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  7. L. Lv
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  8. J. Zhao
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Corresponding author

Correspondence to L. Shen.

Additional information

Yanping Yang contributed equally to this work.

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Shuai, B., Yang, Y.P., Shen, L. et al. Local renin-angiotensin system is associated with bone mineral density of glucocorticoid-induced osteoporosis patients. Osteoporos Int 26, 1063–1071 (2015). https://doi.org/10.1007/s00198-014-2992-y

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  • DOI: https://doi.org/10.1007/s00198-014-2992-y

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