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Alcohol consumption and hip fracture risk

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Abstract

Summary

The present meta-analysis shows that a nonlinear association between alcohol consumption and the risk of hip fracture was observed. Light alcohol consumption was inversely significantly associated with hip fracture risk, whereas heavy alcohol consumption was associated with an elevated hip fracture risk.

Introduction

Previous studies examining the association between alcohol consumption and the risk of hip fracture have reported conflicting findings. Therefore, we conducted a meta-analysis of prospective cohort studies to assess the association between alcohol consumption and the risk of hip fracture.

Methods

PubMed and EMBASE were searched for prospective cohort studies on the relationship between alcohol consumption and the risk of hip fractures. Relative risks (RR) with 95 % confidence intervals (CI) were derived using random-effects models throughout the whole analysis.

Results

Eighteen prospective cohort studies were included with 3,730,424 participants and 26,168 hip fracture cases. Compared with non-drinkers, the pooled RR of hip fractures for alcohol consumption was 1.03 (95 % CI, 0.91–1.15), with high heterogeneity between studies (P < 0.001, I 2 = 72.6 %). A nonlinear relationship between alcohol consumption and the risk of hip fracture was identified (P nonlinearity = 0.003). Compared with non-drinkers, the pooled RRs of hip fractures were 0.88 (95 % CI, 0.83–0.89) for light alcohol consumption (0.01–12.5 g/day), 1.00 (95 % CI, 0.85–1.14) for moderate alcohol consumption (12.6–49.9 g/day), and 1.71 (95 % CI, 1.41–2.01) for heavy alcohol consumption (≥50 g/day).

Conclusions

There was no evidence of publication bias. In conclusion, a nonlinear association between alcohol consumption and the risk of hip fracture was observed in this meta-analysis. Further, light alcohol consumption was inversely significantly associated with hip fracture risk, whereas heavy alcohol consumption was associated with an elevated hip fracture risk.

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Acknowledgments

This study supported by the Fund for Key National Basic Research Program of China (grant no. 2012CB619101 and 81401852), Natural Science Foundation of Science and Technology Commission of Shanghai Municipality (14ZR1424000), Major Basic Research of Science and Technology Commission of Shanghai Municipality (grant no. 11DJ1400303). The funding sources had no role in the study design, collection, analysis, or interpretation of data, or writing of the report.

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Authors and Affiliations

  1. Department of Clinical Medicine, Shanghai Medical College, Fudan University, Shanghai, China

    X. Zhang

  2. Department of Orthopaedics, Shanghai Key Laboratory of Orthopaedic Implant, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China

    Z. Yu & X. Qu

  3. Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, People’s Republic of China

    M. Yu

  4. Department of Orthopaedics, Shanghai Key Laboratory of Orthopaedic Implant, Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, 639 Zhizaoju Road, Shanghai, 200011, China

    X. Qu

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  1. X. Zhang
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Correspondence to M. Yu or X. Qu.

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Xiaoyu Zhang and Zhifeng Yu contributed equally as first co-authors.

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Zhang, X., Yu, Z., Yu, M. et al. Alcohol consumption and hip fracture risk. Osteoporos Int 26, 531–542 (2015). https://doi.org/10.1007/s00198-014-2879-y

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