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Osteoporosis as an independent risk factor for silent brain infarction and white matter changes in men and women: the PRESENT project

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Abstract

Summary

Previous studies have not demonstrated a relationship between osteoporosis and cerebral infarction in the community, especially in men. We found that osteoporosis may be an independent risk factor for brain white matter change/silent infarction in men, as well as in women.

Purpose

We aimed to study the relationship between low bone mineral density (BMD) and brain white matter changes and/or silent infarcts (WMC/SI).

Methods

This was a community-based, cross-sectional study supported by the regional government. Bone mineral density measurements and brain computed tomography were performed in 646 stroke- and dementia-free subjects (aged 50–75 years).

Results

After adjustment for age, hypertension, diabetes mellitus, dyslipidemia, and current smoking status, the odds ratio (OR) of risk for WMC and/or SI was 1.8 in the osteopenia group (95 % confidence interval [CI] 1.15–2.77; P = 0.01) and 2.2 in the osteoporosis group (95 % CI 1.42–3.55; P < 0.001). Among men, the OR was 1.8 (95 % CI 0.72–4.62; P = 0.21) and 3.8 (95 % CI 1.63–8.86; P = 0.002), and in women, the OR was 1.9 (95 % CI 1.15–2.78; P = 0.010) and 2.2 (95 % CI 1.42–3.55; P = 0.001), respectively.

Conclusions

Severe bone mass loss may be an independent risk factor for brain WMC/SI in men and women. Low BMD may cause brain WMC/SI in the step that leads to stroke. Although there are well-designed studies on the prevention of cerebral infarction in patients with brain WMC/SI, a specific prevention method, such as aspirin, should be used for patients with low BMD who have WMC/SI. Screening for low BMD as an independent vascular risk factor in healthy subjects may be required to prevent stroke.

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Acknowledgments

This study was supported by Ansan City, Gyeonggi Province, Korea

Ethics statement

The study protocol was reviewed and approved by the institutional review board of Wonkwang University Hospital (IRB no. 1425).

Conflicts of interest

None.

Author information

Authors and Affiliations

  1. Department of Neurology, Hallym University, Seoul, South Korea

    Y. K. Minn

  2. Department of Neurology, Wonkwang University Sanbon Medical Center, Gunpo-si, South Korea

    S. H. Suk

  3. Wonkwang University Ansan Municipal Geriatric Hospital and Center for Prevention of Stroke and Dementia, Ansan, South Korea

    S. H. Suk & S. Y. Do

  4. Department of Neurology, Wonkwang University Sanbon Medical Center and Ansan Municipal Geriatric Hospital, 1142 Gunpo-si, Gyeonggi-do, 435-040, Korea

    S. H. Suk

Authors
  1. Y. K. Minn
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Correspondence to S. H. Suk.

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Minn, Y.K., Suk, S.H. & Do, S.Y. Osteoporosis as an independent risk factor for silent brain infarction and white matter changes in men and women: the PRESENT project. Osteoporos Int 25, 2465–2469 (2014). https://doi.org/10.1007/s00198-014-2785-3

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  • DOI: https://doi.org/10.1007/s00198-014-2785-3

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