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Vitamin D receptor variability and physical activity are jointly associated with low handgrip strength and osteoporosis in community-dwelling elderly people in Taiwan: the Taichung Community Health Study for Elders (TCHS-E)

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Abstract

Summary

We studied 472 elders to assess joint association of vitamin D receptor (VDR) variability and physical activity on low handgrip strength (LHS) and osteoporosis (OST). Our findings showed that higher risks of OST were associated with physically inactive elders with some specific VDR variations, highlighting the importance of promotion program for physical activity.

Introduction

The aim of this study was to determine the joint association between VDR variability and physical activity on LHS and OST in community-dwelling elders.

Methods

Bone mineral density of the lumbar spine (LS), the femoral neck (FN), and the total hip were measured by dual-energy X-ray absorptiometry. Four single-nucleotide polymorphisms (SNPs) (rs7975232, rs1544410, rs2239185, and rs3782905) of the VDR gene were examined in 472 participants.

Results

Physical inactivity and each of the four SNPs were jointly associated with a significantly greater risk of LHS in people than that associated with each of the VDR SNPs or low physical activity alone. Physically inactive men with the AG or AA genotype of rs2239185 had a significantly greater risk of overall, LS, and FN OST than those of physically active men with the GG genotype [odds ratio (OR) 3.57, 95 % confidence interval (CI) 1.10–11.65; OR 4.74, 95 % CI 1.43–15.70; and OR 5.06, 95 % CI 1.08–23.71, respectively]. Similarly, physically inactive women with the CG or CC genotype of rs3782905 and the AG or AA genotype of rs1544410 had a significantly greater risk of FN OST than physically active women with the GG genotype (OR 5.33, 95 % CI 1.23–23.06 and OR 5.36, 95 % CI 1.11–25.94, respectively).

Conclusions

VDR polymorphisms and physical activity are jointly associated with LHS and OST in elders. Health care programs should promote physical activity among elders as a cost-effective way to prevent LHS and OST, especially in those who may be genetically predisposed.

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Acknowledgments

This study was supported by grants from the National Health Research Institutes of Taiwan (NHRI-EX98-9838PI), China Medical University (CMU102-S-17), and the Taiwan Department of Health Clinical Trial and Research Center of Excellence (DOH102-TD-B-111-004).

Conflicts of interest

None.

Author information

Authors and Affiliations

  1. Department of Public Health, College of Public Health, China Medical University, Taichung, Taiwan

    F.-Y. Wu & L.-N. Liao

  2. Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan

    C.-S. Liu, C.-H. Lin, W.-Y. Lin & C.-C. Lin

  3. School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan

    C.-S. Liu, C.-I. Li, C.-H. Lin, N.-H. Meng, W.-Y. Lin, C.-K. Chang & C.-C. Lin

  4. Department of Medical Research, China Medical University Hospital, Taichung, Taiwan

    C.-I. Li & C.-W. Yang

  5. Ph.D. Program for Aging, College of Medicine, China Medical University, Taichung, Taiwan

    C.-H. Lin & C.-W. Yang

  6. Department of Physical Medicine and Rehabilitation, China Medical University Hospital, Taichung, Taiwan

    N.-H. Meng & C.-K. Chang

  7. Bioinformatics and Biostatistics Core, Center of Genomic Medicine, National Taiwan University, Taipei City, Taiwan

    J.-H. Hsiao

  8. Graduate Institute of Biostatistics, College of Management, China Medical University, 91 Hsueh-Shih Road, Taichung, 40402, Taiwan

    T.-C. Li

  9. Department of Healthcare Administration, College of Health Science, Asia University, Taichung, Taiwan

    T.-C. Li

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  1. F.-Y. Wu
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  2. C.-S. Liu
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Correspondence to T.-C. Li or C.-C. Lin.

Additional information

F.-Y. Wu and C.-S. Liu contributed equally as the first authors.

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Wu, FY., Liu, CS., Liao, LN. et al. Vitamin D receptor variability and physical activity are jointly associated with low handgrip strength and osteoporosis in community-dwelling elderly people in Taiwan: the Taichung Community Health Study for Elders (TCHS-E). Osteoporos Int 25, 1917–1929 (2014). https://doi.org/10.1007/s00198-014-2691-8

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