Gender differences in the relationships between lean body mass, fat mass and peak bone mass in young adults
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
The relationships between fat mass and bone mass in young adults are unclear. In 1,183 young Australians, lean body mass had a strong positive relationship with total body bone mass in both genders. Fat mass was a positive predictor of total body bone mass in females, with weaker association in males.
Body weight and lean body mass are established as major determinants of bone mass, but the relationships between fat mass (including visceral fat) and peak bone mass in young adults are unclear. The aim of this study was to evaluate the associations between bone mass in young adults and three body composition measurements: lean body mass, fat mass and trunk-to-limb fat mass ratio (a surrogate measure of visceral fat).
Study participants were 574 women and 609 men aged 19–22 years from the Raine study. Body composition, total body bone mineral content (TBBMC), bone area and areal bone mineral density (TBBMD) were measured using DXA.
In multivariate linear regression models with height, lean body mass, fat mass and trunk-to-limb fat mass ratio as predictor variables, lean mass was uniquely associated with the largest proportion of variance of TBBMC and TBBMD in males (semi-partial R 2 0.275 and 0.345, respectively) and TBBMC in females (semi-partial R 2 0.183). Fat mass was a more important predictor of TBBMC and TBBMD in females (semi-partial R 2 0.126 and 0.039, respectively) than males (semi-partial R 2 0.006 and 0.018, respectively). Trunk-to-limb fat mass ratio had a weak, negative association with TBBMC and bone area in both genders (semi-partial R 2 0.004 to 0.034).
Lean body mass has strong positive relationship with total body bone mass in both genders. Fat mass may play a positive role in peak bone mass attainment in women but the association was weaker in men; different fat compartments may have different effects.
- Gender differences in the relationships between lean body mass, fat mass and peak bone mass in young adults
Volume 25, Issue 5 , pp 1563-1570
- Cover Date
- Print ISSN
- Online ISSN
- Springer London
- Additional Links
- Fat mass
- Lean body mass
- Peak bone mass
- Raine Study
- Trunk-to-limb fat mass ratio
- Young adults
- Industry Sectors
- Author Affiliations
- 1. Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, WA, 6009, Australia
- 2. School of Medicine and Pharmacology, University of Western Australia, Crawley, Australia
- 3. School of Physiotherapy, Curtin University, Perth, Australia
- 4. Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Australia
- 5. Curtin Health Innovation Research Institute, Curtin University, Perth, Australia
- 6. Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
- 7. School of Women’s and Infants’ Health, University of Western Australia, Crawley, Australia