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Greater risk of hip fracture in hemodialysis than in peritoneal dialysis

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Abstract

Summary

Several differences may have existed between patients treated with peritoneal dialysis and hemodialysis because of the difference in dialysis modality. This nationwide population-based cohort study demonstrated that patients on hemodialysis had an increased risk of hip fracture compared to patients on peritoneal dialysis; the hazard ratio was 1.52.

Introduction

Numerous debates on which dialysis modality is “superior” have taken place in recent decades. However, no large-scale study has ever mentioned about the relationship between dialysis modality and risk of hip fracture.

Methods

We identified 64,124 incident end-stage renal disease patients from the National Health Insurance Research Database in Taiwan between 1998 and 2008, including 59,457 (92.72 %) hemodialysis (HD) and 4,667 (7.28 %) peritoneal dialysis (PD) patients. After 8:1 propensity score matching, 31,554 patients, of whom 28,048 were HD and 3,506 were PD patients, were included in the study. We conducted the Cox proportional hazards model to examine the effects of dialysis modality and other variables on hip fracture risk.

Results

A total of 2,587 hip fractures were identified in 64,124 dialysis patients. The incidence rate of hip fracture was 13.60 per 1000 patient-years in the HD group and 6.25 in the PD group. Dialysis modality, sex, age, presence of cardiovascular disease, diabetes, medication with antiepileptic drugs, diuretics, steroids, and vitamin D had statistically significant associations with hip fracture. Patients on HD had an increased risk of hip fracture compared to patients on PD; the hazard ratio (HR) was 1.52 (95 % CI: 1.09–2.12, P = 0.02).

Conclusions

In this population-based cohort study, HD had a greater hip fracture risk compared to PD; the HR was 1.52. We should focus more on reducing the risk of hip fractures in hemodialysis patients.

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Acknowledgments

This study is based on the data from the National Health Insurance Research Database provided by the Bureau of National Health Insurance, Department of Health, Taiwan. This work was supported by China Medical University and Asia University (grant numbers CMU99-ASIA-18 and DOH101-TD-B-111-004).

Conflicts of interest

None

Author information

Authors and Affiliations

  1. Department of Health Services Administration, China Medical University, 91 Hsueh-Shih Road, Taichung, Taiwan, 40402, Republic of China

    Y.-J. Chen, Y.-H. Wang & W.-C. Tsai

  2. Department of Orthopedic Surgery, China Medical University Hospital, Taichung, Taiwan

    Y.-J. Chen & H.-C. Hsu

  3. School of Medicine, China Medical University, Taichung, Taiwan

    Y.-J. Chen & H.-C. Hsu

  4. Department of Health Administration, Asia University, Taichung, Taiwan

    P.-T. Kung

  5. Division of Nephrology, China Medical University Hospital, Taichung, Taiwan

    C.-C. Huang

  6. Landseed Hospital, TaoYuan, Taiwan

    S.-C. Hsu

Authors
  1. Y.-J. Chen
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  2. P.-T. Kung
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  3. Y.-H. Wang
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  4. C.-C. Huang
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  5. S.-C. Hsu
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  6. W.-C. Tsai
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  7. H.-C. Hsu
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Corresponding author

Correspondence to W.-C. Tsai.

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Chen, YJ., Kung, PT., Wang, YH. et al. Greater risk of hip fracture in hemodialysis than in peritoneal dialysis. Osteoporos Int 25, 1513–1518 (2014). https://doi.org/10.1007/s00198-014-2632-6

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  • DOI: https://doi.org/10.1007/s00198-014-2632-6

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