Osteoporosis International

, Volume 24, Issue 1, pp 179–186

Prevalence and seasonal variation of hypovitaminosis D and its relationship to bone metabolism in healthy Hungarian men over 50 years of age: the HunMen Study

  • H. P. Bhattoa
  • E. Nagy
  • C. More
  • J. Kappelmayer
  • A. Balogh
  • E. Kalina
  • P. Antal-Szalmas
Original Article

DOI: 10.1007/s00198-012-1920-2

Cite this article as:
Bhattoa, H.P., Nagy, E., More, C. et al. Osteoporos Int (2013) 24: 179. doi:10.1007/s00198-012-1920-2

Abstract

Summary

This study reports a high prevalence of hypovitaminosis D and low bone mineral density (BMD) in a healthy Hungarian male cohort over 50 years of age. Men with 25-hydroxyvitamin D levels of <75 nmol/L had a significantly higher 10-year hip and major osteoporotic fracture probability using the country-specific fracture risk assessment (FRAX) algorithm.

Introduction

The aim of this study is to characterize the prevalence and seasonal variation of hypovitaminosis D and its relationship to bone metabolism in healthy Hungarian men over 50 years of age.

Methods

We determined levels of 25-hydroxyvitamin D (25-OH-D), PTH, osteocalcin (OC), C-terminal telopeptides of type-I collagen (CTX-I), procollagen type 1 amino-terminal propeptide (PINP), BMD at L1–L4 (LS) and femur neck (FN), daily dietary calcium intake, and the 10-year probability of hip fracture and a major osteoporotic fracture using the country-specific FRAX algorithm in 206 randomly selected ambulatory men.

Results

The mean (range) age of the volunteers was 60 (51–81) years. The prevalence of hypovitaminosis D (25-OH-D, <75 nmol/L) was 52.9%. The prevalence of low (T-score < −1.0) BMD at the FN and LS was 45% and 35.4%, respectively. The mean (range) FRAX hip fracture and FRAX major osteoporotic fracture was 0.8% (0–9.4%) and 3.8% (1.7–16%), respectively. On comparing the vitamin D sufficient to the insufficient group, there was a statistically significant difference between the FRAX hip fracture and FRAX major osteoporotic fracture indexes. There was significant seasonal variation in the vitamin D levels; the lowest levels were measured in winter and the highest in summer.

Conclusions

A high prevalence of hypovitaminosis D and low BMD were observed in the studied Hungarian male population. This is the first study reporting higher 10-year hip and major osteoporotic fracture probability using the country-specific FRAX algorithm in individuals with hypovitaminosis D.

Keywords

Bone healthBone markersFRAXMenVitamin D

Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2012

Authors and Affiliations

  • H. P. Bhattoa
    • 1
    • 2
  • E. Nagy
    • 1
  • C. More
    • 2
  • J. Kappelmayer
    • 1
  • A. Balogh
    • 2
  • E. Kalina
    • 1
  • P. Antal-Szalmas
    • 1
  1. 1.Department of Laboratory MedicineMedical and Health Science Center, University of DebrecenDebrecenHungary
  2. 2.Regional Osteoporosis Center, Department of Obstetrics and GynecologyMedical and Health Science Center, University of DebrecenDebrecenHungary