Review

Osteoporosis International

, Volume 20, Issue 7, pp 1101-1106

Monitoring strontium ranelate therapy in patients with osteoporosis

  • D. L. KendlerAffiliated withUniversity of British Columbia Email author 
  • , J. D. AdachiAffiliated withDepartment of Medicine, St. Joseph’s Healthcare, McMaster University
  • , R. G. JosseAffiliated withOsteoporosis Centre, St. Michael’s Hospital, University of Toronto
  • , D. O. SlosmanAffiliated withInstitut de Médecine Nucléaire, 20 Chemin Beausoleil, Clinique Générale Beaulieu

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Abstract

Purpose

The purpose of this study was to review the monitoring of strontium ranelate osteoporosis therapy.

Methods

The method used in this study was comprehensive literature review with clinical perspectives.

Results

Changes in bone turnover markers (BTM) or bone mineral density (BMD) have been documented in osteoporosis clinical trials. However, neither BMD nor BTM changes fully explain the observed fracture risk reduction in treated patients. If changes in BMD or BTM on therapy would be easily discernable in individual patients, and were strongly associated with fracture risk reduction, monitoring individuals would be more useful. BMD changes in patients on strontium ranelate are of a greater magnitude and hence can be easily determined in an individual patient. In addition, there exists a better correlation between fracture risk reduction and increases in BMD.

Conclusions

The strong correlation between measured BMD increases and fracture risk reduction in patients on strontium ranelate therapy will be of clinical benefit to physicians wishing to evaluate both treatment persistence and fracture risk reduction.

Keyword

Bone mineral density Bone turnover markers Monitoring osteoporosis therapy Strontium ranelate