, Volume 18, Issue 9, pp 1153-1156
Date: 05 Jul 2007

Individualization of osteoporosis risk

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Anti-fracture therapy is often pursued in individuals with osteoporosis or low bone mineral density with or without a prior fracture [13], because they are at high risk of subsequent fracture [4, 5]. In recent years, there has been a proliferation of clinical prediction rules, including clinical risk indices and scores, for identifying individuals with osteoporosis. The main problem with these clinical prediction rules is that they categorize individuals into low-risk versus high-risk groups based on some arbitrary threshold. As a result, when this risk stratification-based approach is applied to an individual, its prognostic performance is often poor.

Among the clinical indices for predicting osteoporosis, the Osteoporosis Self-Assessment tool (OST) [6] is perhaps the simplest score and has perhaps been the most widely studied. However, the clinical usefulness of this score in different populations has not been systematically studied. In this issue, Rud and colleagues [7] systematical ...