, Volume 18, Issue 8, pp 1141-1143
Date: 17 Feb 2007

Estimates of fracture probability in Denmark

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Dear Editors,

The predictive value of DXA for fracture risk assessment has been established in many studies. The meta-analysis of Marshall et al. [1] found that the risk of any osteoporotic fracture increased 1.6-fold for each standard deviation decrease in bone mineral density. More recently it has become evident that there are important interactions that modulate the performance characteristics of BMD. For example, age provides an element of risk not captured by BMD. Thus, the 10-year probability of hip fracture in women aged 80 years with a T-score of −2.5 SD at the femoral neck is fivefold higher than that found in a woman at the age of 50 years with an identical T-score [2]. There is also a complex interaction of age with BMD. Whereas the average gradient of risk for hip fracture in men and women is approximately 2.6 per SD decrease in BMD at the femoral neck [1], it is significantly higher at the age of 50 years (3.68) than at the age of 85 years (1.93) [3]. More recently it has b

A reply to this letter can be found at doi: 10.1007/s00198-007-0347-7.