Osteoporosis International

, Volume 18, Issue 7, pp 999–1008

The association of bone mineral density measures with incident cardiovascular disease in older adults

  • G. N. Farhat
  • A. B. Newman
  • K. Sutton-Tyrrell
  • K. A. Matthews
  • R. Boudreau
  • A. V. Schwartz
  • T. Harris
  • F. Tylavsky
  • M. Visser
  • J. A. Cauley
  • for the Health ABC study
Original Article

DOI: 10.1007/s00198-007-0338-8

Cite this article as:
Farhat, G.N., Newman, A.B., Sutton-Tyrrell, K. et al. Osteoporos Int (2007) 18: 999. doi:10.1007/s00198-007-0338-8

Abstract

Summary

The associations of volumetric and areal bone mineral density (BMD) measures with incident cardiovascular disease (CVD) were studied in a biracial cohort of 2,310 older adults. BMD measures were inversely related to CVD in women and white men, independent of age and shared risk factors for osteoporosis and CVD.

Introduction

We investigated the associations of volumetric (vBMD) and areal (aBMD) bone mineral density measures with incident cardiovascular disease (CVD) in older adults enrolled in the Health, Aging, and Body Composition study.

Methods

The incidence of CVD was ascertained in 2,310 well-functioning white and black participants (42% black; 55% women), aged 68–80 years. aBMD measures of the hip were assessed using DXA. Spine trabecular, integral, and cortical vBMD measures were obtained using QCT.

Results

During an average follow-up of 5.4 years, 23% of men and 14% of women had incident CVD. Spine vBMD measures were inversely associated with incident CVD in white men [HR(integral)=1.39, 95% CI 1.03–1.87; HR(cortical)=1.38, 95% CI 1.03–1.84], but not in black men. In women, aBMD measures of the total hip (HR = 1.36, 95% CI 1.03–1.78), femoral neck (HR = 1.44, 95% CI 1.10–1.90), and trochanter (HR = 1.34, 95% CI 1.04–1.72) exhibited significant associations with CVD in blacks, but not in whites. All associations were independent of age and shared risk factors between osteoporosis and CVD, and were not explained by inflammatory cytokines or oxidized LDL.

Conclusion

Our results provide support for an inverse association between BMD and incident CVD. Further research should elucidate possible pathophysiological mechanisms linking osteoporosis and CVD.

Keywords

Areal BMDIncident cardiovascular diseaseInflammatory cytokinesOxidized LDLVolumetric BMD

Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2007

Authors and Affiliations

  • G. N. Farhat
    • 1
    • 6
  • A. B. Newman
    • 1
  • K. Sutton-Tyrrell
    • 1
  • K. A. Matthews
    • 1
  • R. Boudreau
    • 1
  • A. V. Schwartz
    • 2
  • T. Harris
    • 3
  • F. Tylavsky
    • 4
  • M. Visser
    • 5
  • J. A. Cauley
    • 1
  • for the Health ABC study
  1. 1.Department of Epidemiology, Graduate School of Public HealthUniversity of PittsburghPittsburghUSA
  2. 2.Department of Epidemiology and BiostatisticsUniversity of CaliforniaSan FranciscoUSA
  3. 3.Laboratory of Epidemiology, Demography, and Biometry, Intramural Research ProgramNational Institute on AgingBethesdaUSA
  4. 4.Department of Preventive MedicineUniversity of Tennessee Health Science CenterMemphisUSA
  5. 5.Institute for Research in Extramural Medicine, VU Medical Center and Institute of Health SciencesVrije UniversiteitAmsterdamThe Netherlands
  6. 6.Division of Cancer Prevention and Population ScienceUniversity of PittsburghPittsburghUSA