Abstract
Rapid prototyping techniques are increasingly used to build porous scaffolds for the regeneration of biological tissues. This paper deals with one of the most critical tasks involved by this option, i.e., the preparation of geometric data for layered fabrication. Compared to other existing approaches, this work aims at both reducing the required effort in interactive modeling and allowing a standard use of commercial prototyping systems without resorting to special treatments. The proposed method adds a porous structure to the geometric model of tissue surface in polygon format. The structure is of the Cartesian type and consists of an interconnected network of rectilinear channels, whose dimensions can be varied according to desired porosity and pore size. The algorithmic procedures needed for the generation of the porous structure have been implemented in a demonstrative software tool. Sample models of scaffolds have been generated and used to build prototype parts by different fabrication processes and systems.
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References
Hutmacher DW (2000) Scaffolds in tissue engineering bone and cartilage. Biomaterials 21:2529–2543
Leong KF, Cheah CM, Chua CK (2003) Solid freeform fabrication of three-dimensional scaffolds for engineering replacement tissues and organs. Biomaterials 24:2363–2378
Yang S, Leong KF, Du Z, Chua CK (2002) The design of scaffolds for tissue engineering. Part II: rapid prototyping techniques. Tissue Eng 8:1–11
Das S, Hollister SJ, Flanagan C, Adewunmi A, Bark K, Chen C, Ramaswamy K, Rose D, Widjaja E (2003) Freeform fabrication of nylon-6 tissue engineering scaffolds. Rapid Prototyping J 9–1:43–49
Tan KH, Chua CK, Leong KF, Cheah CM, Cheang P, Abu Bakar MS, Cha SW (2003) Scaffold development using selective laser sintering of polyetheretherketone-hydroxyapatite biocomposite blends. Biomaterials 24:3115–3123
Williams JM, Adewunmi A, Schek RM, Flanagan CL, Krebsbach PH, Feinberg SE, Hollister SJ, Das S (2005) Bone tissue engineering using caprolactone scaffolds fabricated via selective laser sintering. Biomaterials 26:4817–4827
Wu BM, Borland SW, Giordano RA, Cima LG, Sachs EM, Cima MJ (1996) Solid free-form fabrication of drug delivery devices. J Contr Release 40:77–87
Lam CXF, Mo XM, Teoh SH, Hutmacher DW (2002) Scaffold development using 3D printing with a starch-based polymer. Mater Sci Eng C 20:49–56
Zein I, Hutmacher D, Tan KC, Teoh SH (2002) Fused deposition modeling of novel scaffold architectures for tissue engineering applications. Biomaterials 23:1169–1185
Too MH, Leong KF, Chua CK, Du ZH, Yang SF, Cheah CM, Ho SL (2002) Investigation of 3D non-random porous structures by fused deposition modeling. Int J Adv Manuf Tech 19:217–223
Ang TH, Sultana FSA, Hutmacher DW, Wong YS, Fuh JYH, Mo XM, Loh HT, Burdet E, Teoh SH (2002) Fabrication of 3D chitosan hydroxyapatite scaffold using a robotic dispensing system. Mater Sci Eng C 20:35–42
Xiong Z, Yan Y, Wang S, Zhang R, Zhang C (2002) Fabrication of porous scaffolds for bone tissue engineering via low-temperature deposition. Scripta Mater 46:771–776
Yan Y, Wu R, Zhang R, Xiong Z, Lin F (2003) Biomaterial forming research using RP technology. Rapid Prototyping J 9:142–149
Landers R, Pfister A, Hübner U, John H, Schmelzeisen R, Mühlaupt R (2002) Fabrication of soft tissue engineering scaffolds by means of rapid prototyping techniques. J Mater Sci 37:3107–3116
Landers R, Hübner U, Schmelzeisen R, Mühlaupt R (2002) Rapid prototyping of scaffolds derived from thermoreversible hydrogels and tailored for applications in tissue engineering. Biomaterials 23:4437–4447
Calvert P, Liu Z (1998) Freeform fabrication of hydrogels. Acta Mater 46:2565–2571
Vozzi G, Flaim C, Ahluwalia A, Bhatia S (2003) Fabrication of PLGA scaffolds using soft lithography and microsyringe deposition. Biomaterials 24:2533–2540
Wang F, Shor L, Darling A, Khalil S, Sun W, Güçeri S, Lau A (2004) Precision extruding deposition and characterization of cellular poly-ɛ-caprolactone tissue scaffolds. Rapid Prototyping J 10–1:42–49
Chen Z, Li D, Lu B, Tang Y, Sun M, Wang Z (2004) Fabrication of artificial bioactive bone using rapid prototyping. Rapid Prototyping J 10–5:327–333
Chen Z, Li D, Lu B, Tang Y, Sun M, Xu S (2005) Fabrication of osteo-structure analogous scaffolds via fused deposition modeling. Scripta Mater 52:157–161
Khalil S, Nam J, Sun W (2005) Multi-nozzle deposition for construction of 3D biopolymer tissue scaffolds. Rapid Prototyping J 11–1:9–17
Geng L, Feng W, Hutmacher DW, Wong YS, Loh HT, Fuh JYH (2005) Direct writing of chitosan scaffolds using a robotic system. Rapid Prototyping J 11–2:90–97
Bose S, Darsell J, Hosick HL, Yang L, Sarkar DK, Bandyopadhyay A (2002) Processing and characterization of porous alumina scaffolds. J Mater Sci Mater Med 13:23–28
Chu TMG, Orton DG, Hollister SJ, Feinberg SE, Halloran JW (2002) Mechanical and in vivo performance of hydroxyapatite implants with controlled architectures. Biomaterials 23:1283–1293
Taboas JM, Maddox RD, Krebsbach PH, Hollister SJ (2003) Indirect solid free form fabrication of local and global porous, biomimetic and composite 3D polymer-ceramic scaffolds. Biomaterials 24:181–194
Lee M, Dunn JCY, Wu BM (2005) Scaffold fabrication by indirct three-dimensional printing. Biomaterials 26:4281–4289
Schroeder C, Regli WC, Shokoufandeh A, Sun W (2005) Computer-aided design of porous artifacts. Comput Aided Des 37:339–353
Fang Z, Starly B, Sun W (2005) Computer-aided characterization for effective mechanical properties of porous tissue scaffolds. Comput Aided Des 37:65–72
Lal P, Sun W (2004) Computer modeling approach for microsphere-packed bone scaffold. Comput Aided Des 36:487–497
Hollister SJ, Maddox RD, Taboas JM (2002) Optimal design and fabrication of scaffolds to mimic tissue properties and satisfy biological constraints. Biomaterials 23:4095–4103
Chua CK, Leong KF, Chea CM, Chua SW (2003) Development of a tissue engineering scaffold structure library for rapid prototyping. The Int. J. of Advanced Manufacturing Technology 21:291-312
Fadel GM, Kirschman C (1996) Accuracy issues in CAD to RP translation. Rapid Prototyping J 2–2:4–17
Ferguson RS (2001) Practical algorithms for 3D computer graphics. A K Peters, Natick, MA
O’Rourke J (1994) Computational geometry in C. Cambridge University Press, Cambridge
Lorensen WE, Cline HE (1987) Marching cubes: a high resolution 3D surface construction algorithm. Comput Graph 21–4:163–169
Pelzer R, Ott A (2004) Fabrication of scaffold structures by rapid prototyping methods. Proc. Int. Design Conference, Dubrovnik, pp 453–458
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Armillotta, A., Pelzer, R. Modeling of porous structures for rapid prototyping of tissue engineering scaffolds. Int J Adv Manuf Technol 39, 501–511 (2008). https://doi.org/10.1007/s00170-007-1247-x
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DOI: https://doi.org/10.1007/s00170-007-1247-x