Skip to main content
Log in

Symptoms and function in patients with articular cartilage lesions in 1,000 knee arthroscopies

  • Knee
  • Published:
Knee Surgery, Sports Traumatology, Arthroscopy Aims and scope

Abstract

Purpose

Focal chondral lesions of the knee are commonly occurring. A lot is known about their frequency, size and localisation in arthroscopic series, but less about the symptoms they elicit and little about how the arthroscopic findings and symptoms correlate. The purposes of the present study included to investigate the relationship between articular cartilage lesion factors and patient factors, and to compare the symptoms and function of cartilage lesion patients to those of patients with a deficient ACL.

Methods

A prospective registration was conducted of preoperative data including Lysholm knee score and perioperative findings in 1,000 consecutive patients undergoing an arthroscopic procedure of the knee—including microfracture of articular cartilage defects and ACL reconstructions.

Results

Chondral or osteochondral lesions were found in 57 % of the arthroscopies. The mean Lysholm score in this subgroup was 55. The mean Lysholm score was significantly lower in women (50, SD 19) compared to men (59, SD 18, p < 0.001). Among the chondral lesion factors, only kissing (vs. non-kissing) lesions and multiple (vs. single) lesions influenced symptoms and function to a more than negligible degree. Microfracture in one or two articular cartilage defects was performed in 187 patients. The microfracture group had a significant lower mean Lysholm score (54, SD 18) than a group of patients (N = 71) undergoing ACL reconstruction group (67, SD 17, p < 0.001).

Conclusion

The study confirms that articular cartilage lesions are both common and cumbersome. Women seem to have more problems than men, whereas chondral lesion factors—such as localisation and size—seem to influence symptoms and function to a small degree. These aspects should be addressed when designing outcome studies, and should also be of interest to the orthopaedic surgeon—in the day-by-day clinical work. When treating these patients, our prime focus need to be on knee function rather than the cartilage defect as the relationship between the latter and the former is unclear.

Level of evidence

Case–control study, Level III.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Ageberg E, Roberts D, Holmström E, Fridén T (2005) Balance in single-limb stance in patients with anterior cruciate ligament injury: relation to knee laxity, proprioception, muscle strength, and subjective function. Am J Sports Med 33:1527–1535

    Article  PubMed  Google Scholar 

  2. Arøen A, Løken S, Heir S, Alvik E, Ekeland A, Granlund OG, Engebretsen L (2004) Articular cartilage lesions in 993 consecutive knee arthroscopies. Am J Sports Med 32:211–215

    Article  PubMed  Google Scholar 

  3. Basad E, Ishaque B, Bachmann G, Stürz H, Steinmeyer J (2010) Matrix-induced autologous chondrocyte implantation versus microfracture in the treatment of cartilage defects of the knee: a 2-year randomised study. Knee Surg Sports Traumatol Arthr 18:519–527

    Article  Google Scholar 

  4. Bellamy N, Buchanan WW, Goldsmith CH, Campbell J, Stitt LW (1988) Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. J Rheumatol 15:1833–1840

    CAS  PubMed  Google Scholar 

  5. Bingefors K, Isacson D (2004) Epidemiology, co-morbidity, and impact on health-related quality of life of self-reported headache and musculoskeletal pain—a gender perspective. Eur J Pain 8:435–450

    Article  PubMed  Google Scholar 

  6. Blevins FT, Steadman JR, Rodrigo JJ, Silliman J (1998) Treatment of articular cartilage defects in athletes: an analysis of functional outcome and lesion appearance. Orthopedics 21:761–767 discussion 767–768

    CAS  PubMed  Google Scholar 

  7. Bodnar RJ, Romero MT, Kramer E (1988) Organismic variables and pain inhibition: roles of gender and aging. Brain Res Bull 21:947–953

    Article  CAS  PubMed  Google Scholar 

  8. Briggs KK, Steadman JR, Hay CJ, Hines SL (2009) Lysholm score and tegner activity level in individuals with normal knees. Am J Sports Med 37:898–901

    Article  PubMed  Google Scholar 

  9. Brittberg M, Lindahl A, Nilsson A, Ohlsson C, Isaksson O, Peterson L (1994) Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med 331:889–895

    Article  CAS  PubMed  Google Scholar 

  10. Brittberg M, Winalski CS (2003) Evaluation of cartilage injuries and repair. J Bone Joint Surg Am 85-A(Suppl. 2):58–69

    PubMed  Google Scholar 

  11. Cole BJ, Farr J, Winalski CS, Hosea T, Richmond J, Mandelbaum B, De Deyne PG (2011) Outcomes after a single-stage procedure for cell-based cartilage repair: a prospective clinical safety trial with 2-year follow-up. Am J Sports Med 39:1170–1179

    Article  PubMed  Google Scholar 

  12. Collins NJ, Misra D, Felson DT, Crossley KM, Roos EM (2011) Measures of knee function: International Knee Documentation Committee (IKDC) Subjective Knee Evaluation Form, Knee Injury and Osteoarthritis Outcome Score (KOOS), Knee Injury and Osteoarthritis Outcome Score Physical Function Short Form (KOOS-PS), Knee Ou. Arthritis Care Res 63:S208–S228

    Article  Google Scholar 

  13. Curl WW, Krome J, Gordon ES, Rushing J, Smith BP, Poehling GG (1997) Cartilage injuries: a review of 31,516 knee arthroscopies. Arthroscopy 13:456–460

    Article  CAS  PubMed  Google Scholar 

  14. Dzioba RB (1988) The classification and treatment of acute articular cartilage lesions. Arthroscopy 4:72–80

    Article  CAS  PubMed  Google Scholar 

  15. Erdil M, Bilsel K, Taser OF, Sen C, Asik M (2013) Osteochondral autologous graft transfer system in the knee; mid-term results. Knee 20:2–8

    Article  PubMed  Google Scholar 

  16. Flandry F, Hunt JP, Terry GC, Hughston JC (1991) Analysis of subjective knee complaints using visual analog scales. Am J Sports Med 19:112–118

    Article  CAS  PubMed  Google Scholar 

  17. Flor H, Turk DC, Rudy TE (1989) Relationship of pain impact and significant other reinforcement of pain behaviors: the mediating role of gender, marital status and marital satisfaction. Pain 38:45–50

    Article  CAS  PubMed  Google Scholar 

  18. Gudas R, Kalesinskas RJ, Kimtys V, Stankevicius E, Toliusis V, Bernotavicius G, Smailys A (2005) A prospective randomized clinical study of mosaic osteochondral autologous transplantation versus microfracture for the treatment of osteochondral defects in the knee joint in young athletes. Arthroscopy 21:1066–1075

    Article  PubMed  Google Scholar 

  19. Hangody L, Kish G, Kárpáti Z, Udvarhelyi I, Szigeti I, Bély M (1998) Mosaicplasty for the treatment of articular cartilage defects: application in clinical practice. Orthopedics 21:751–756

    CAS  PubMed  Google Scholar 

  20. Hjelle K, Solheim E, Strand T, Muri R, Brittberg M (2002) Articular cartilage defects in 1,000 knee arthroscopies. Arthroscopy 18:730–734

    Article  PubMed  Google Scholar 

  21. Hunter W (1742) Of the structure and diseases of articulating cartilages. Philos Trans 42:514–521

  22. Jinks C, Jordan KP, Blagojevic M, Croft P (2008) Predictors of onset and progression of knee pain in adults living in the community. A prospective study. Rheumatology 47:368–374

    Article  CAS  PubMed  Google Scholar 

  23. Knutsen G, Engebretsen L, Ludvigsen TC, Drogset JO, Grøntvedt T, Solheim E, Strand T, Roberts S, Isaksen V, Johansen O (2004) Autologous chondrocyte implantation compared with microfracture in the knee. A randomized trial. J Bone Joint Surg Am 86-A:455–464

    PubMed  Google Scholar 

  24. Kocher MS, Steadman JR, Briggs KK, Sterett WI, Hawkins RJ (2004) Reliability, validity, and responsiveness of the Lysholm knee scale for various chondral disorders of the knee. J Bone Joint Surg Am 86-A:1139–1145

    PubMed  Google Scholar 

  25. Kreuz PC, Müller S, von Keudell A, Tischer T, Kaps C, Niemeyer P, Erggelet C (2013) Influence of sex on the outcome of autologous chondrocyte implantation in chondral defects of the knee. Am J Sports Med 41:1541–1548

    Article  PubMed  Google Scholar 

  26. Miller BS, Steadman JR, Briggs KK, Rodrigo JJ, Rodkey WG (2004) Patient satisfaction and outcome after microfracture of the degenerative knee. J Knee Surg 17:13–17

    PubMed  Google Scholar 

  27. O’Driscoll SW (1998) The healing and regeneration of articular cartilage. J Bone Joint Surg Am 80:1795–1812

    PubMed  Google Scholar 

  28. Racine M, Tousignant-Laflamme Y, Kloda LA, Dion D, Dupuis G, Choinière M (2012) A systematic literature review of 10 years of research on sex/gender and experimental pain perception—part 1: are there really differences between women and men? Pain 153:602–618

    Article  PubMed  Google Scholar 

  29. Racine M, Tousignant-Laflamme Y, Kloda LA, Dion D, Dupuis G, Choinière M (2012) A systematic literature review of 10 years of research on sex/gender and pain perception—part 2: do biopsychosocial factors alter pain sensitivity differently in women and men? Pain 153:619–635

    Article  PubMed  Google Scholar 

  30. Ramírez-Maestre C, Esteve R (2014) The role of sex/gender in the experience of pain: resilience, fear, and acceptance as central variables in the adjustment of men and women with chronic pain. J Pain 15:608–618

    Article  PubMed  Google Scholar 

  31. Ruau D, Liu LY, Clark JD, Angst MS, Butte AJ (2012) Sex differences in reported pain across 11,000 patients captured in electronic medical records. J Pain 13:228–234

    Article  PubMed  PubMed Central  Google Scholar 

  32. Rustøen T, Wahl AK, Hanestad BR, Lerdal A, Paul S, Miaskowski C (2004) Gender differences in chronic pain—findings from a population-based study of Norwegian adults. Pain Manag Nurs 5:105–117

    Article  PubMed  Google Scholar 

  33. Salaffi F, Leardini G, Canesi B, Mannoni A, Fioravanti A, Caporali R, Lapadula G, Punzi L, GOnorthrosis and Quality Of Life Assessment (GOQOLA) (2003) Reliability and validity of the Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index in Italian patients with osteoarthritis of the knee. Osteoarthr Cartil 11:551–560

    Article  CAS  PubMed  Google Scholar 

  34. Salzmann GM, Sah B, Südkamp NP, Niemeyer P (2013) Clinical outcome following the first-line, single lesion microfracture at the knee joint. Arch Orthop Trauma Surg 133:303–310

    Article  CAS  PubMed  Google Scholar 

  35. Saris DBF, Vanlauwe J, Victor J, Haspl M, Bohnsack M, Fortems Y, Vandekerckhove B, Almqvist KF, Claes T, Handelberg F, Lagae K, van der Bauwhede J, Vandenneucker H, Yang KGA, Jelic M, Verdonk R, Veulemans N, Bellemans J, Luyten FP (2008) Characterized chondrocyte implantation results in better structural repair when treating symptomatic cartilage defects of the knee in a randomized controlled trial versus microfracture. Am J Sports Med 36:235–246

    Article  PubMed  Google Scholar 

  36. Shelbourne KD, Jari S, Gray T (2003) Outcome of untreated traumatic articular cartilage defects of the knee: a natural history study. J Bone Joint Surg Am 85-A(Suppl 2):8–16

    PubMed  Google Scholar 

  37. Solheim E, Aarseth L, Hjelle K, Brittberg M, Strand T (2000) Symptoms and function in patients with chondral defects of the knee. ICRS 3th Symposium, Gothenburg, Sweden June 2000

  38. Solheim E, Hegna J, Inderhaug E, Øyen J, Harlem T, Strand T (2014) Results at 10–14 years after microfracture treatment of articular cartilage defects in the knee. Knee Surg Sports Traumatol Arthr. doi:10.1007/s00167-014-3443-1

    Google Scholar 

  39. Solheim E, Øyen J, Hegna J, Austgulen OK, Harlem T, Strand T (2010) Microfracture treatment of single or multiple articular cartilage defects of the knee: a 5-year median follow-up of 110 patients. Knee Surg Sports Traumatol Arthrosc 18:504–508

    Article  PubMed  Google Scholar 

  40. Steadman JR, Ramappa AJ, Maxwell RB, Briggs KK (2007) An arthroscopic treatment regimen for osteoarthritis of the knee. Arthroscopy 23:948–955

    Article  PubMed  Google Scholar 

  41. Tegner Y, Lysholm J (1985) Rating systems in the evaluation of knee ligament injuries. Clin Orthop Relat Res 198:43–49

    PubMed  Google Scholar 

  42. Widuchowski W, Widuchowski J, Trzaska T (2007) Articular cartilage defects: study of 25,124 knee arthroscopies. Knee 14:177–182

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Eirik Solheim.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Solheim, E., Krokeide, A.M., Melteig, P. et al. Symptoms and function in patients with articular cartilage lesions in 1,000 knee arthroscopies. Knee Surg Sports Traumatol Arthrosc 24, 1610–1616 (2016). https://doi.org/10.1007/s00167-014-3472-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00167-014-3472-9

Keywords

Navigation