Skip to main content

Advertisement

SpringerLink
Log in

Have renal biomarkers failed in acute kidney injury? Yes

  • Editorial
  • Published:
Intensive Care Medicine Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Mishra J, Dent C, Tarabishi R, Mitsnefes MM, Ma Q, Kelly C, Ruff SM, Zahedi K, Shao M, Bean J, Mori K, Barasch J, Devarajan P (2005) Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery. Lancet 365:1231–1238

    Article  CAS  PubMed  Google Scholar 

  2. Parikh CR, Coca SG, Thiessen-Philbrook H, Shlipak MG, Koyner JL, Wang Z, Edelstein CL, Devarajan P, Patel UD, Zappitelli M, Krawczeski CD, Passik CS, Swaminathan M, Garg AX (2011) Postoperative biomarkers predict acute kidney injury and poor outcomes after adult cardiac surgery. J Am Soc Nephrol 22:1748–1757

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Singer E, Elger A, Elitok S, Kettritz R, Nickolas TL, Barasch J, Luft FC, Schmidt-Ott KM (2011) Urinary neutrophil gelatinase-associated lipocalin distinguishes pre-renal from intrinsic renal failure and predicts outcomes. Kidney Int 80:405–414

    Article  CAS  PubMed  Google Scholar 

  4. Nejat M, Pickering JW, Devarajan P, Bonventre JV, Edelstein CL, Walker RJ, Endre ZH (2012) Some biomarkers of acute kidney injury are increased in pre-renal acute injury. Kidney Int 81:1254–1262

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Haase M, Devarajan P, Haase-Fielitz A, Bellomo R, Cruz DN, Wagener G, Krawczeski CD, Koyner JL, Murray P, Zappitelli M, Goldstein SL, Makris K, Ronco C, Martensson J, Martling CR, Venge P, Siew E, Ware LB, Ikizler TA, Mertens PR (2011) The outcome of neutrophil gelatinase-associated lipocalin-positive subclinical acute kidney injury: a multicenter pooled analysis of prospective studies. J Am Coll Cardiol 57:1752–1761

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Srisawat N, Wen X, Lee M, Kong L, Elder M, Carter M, Unruh M, Finkel K, Vijayan A, Ramkumar M, Paganini E, Singbartl K, Palevsky PM, Kellum JA (2011) Urinary biomarkers and renal recovery in critically ill patients with renal support. Clin J Am Soc Nephrol 6:1815–1823

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Coca SG, Garg AX, Thiessen-Philbrook H, Koyner JL, Patel UD, Krumholz HM, Shlipak MG, Parikh CR, Consortium T-A (2014) Urinary biomarkers of AKI and mortality 3 years after cardiac surgery. J Am Soc Nephrol 25:1063–1071

    Article  CAS  PubMed  Google Scholar 

  8. Koyner JL, Davison DL, Brasha-Mitchell E, Chalikonda DM, Arthur JM, Shaw AD, Tumlin JA, Trevino SA, Bennett MR, Kimmel PL, Seneff MG, Chawla LS (2015) Furosemide stress test and biomarkers for the prediction of AKI severity. J Am Soc Nephrol 26:2023–2031

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Perazella MA, Coca SG, Kanbay M, Brewster UC, Parikh CR (2008) Diagnostic value of urine microscopy for differential diagnosis of acute kidney injury in hospitalized patients. Clin J Am Soc Nephrol 3:1615–1619

    Article  PubMed  PubMed Central  Google Scholar 

  10. Molitoris BA (2015) Urinary biomarkers: alone are they enough? J Am Soc Nephrol 26:1485–1488

    Article  PubMed  Google Scholar 

  11. Vanmassenhove J, Glorieux G, Hoste E, Dhondt A, Vanholder R, Van BW (2013) Urinary output and fractional excretion of sodium and urea as indicators of transient versus intrinsic acute kidney injury during early sepsis. Crit Care 17:1–10

    Article  Google Scholar 

  12. Ralib AM, Pickering JW, Shaw GM, Devarajan P, Edelstein CL, Bonventre JV, Endre ZH (2012) Test characteristics of urinary biomarkers depend on quantitation method in acute kidney injury. J Am Soc Nephrol 23:322–333

    Article  CAS  PubMed  Google Scholar 

  13. Endre ZH, Walker RJ, Pickering JW, Shaw GM, Frampton CM, Henderson SJ, Hutchison R, Mehrtens JE, Robinson JM, Schollum JB, Westhuyzen J, Celi LA, McGinley RJ, Campbell IJ, George PM (2010) Early intervention with erythropoietin does not affect the outcome of acute kidney injury (the EARLYARF trial). Kidney Int 77:1020–1030

    Article  CAS  PubMed  Google Scholar 

  14. Wald R, Adhikari NK, Smith OM, Weir MA, Pope K, Cohen A, Thorpe K, McIntyre L, Lamontagne F, Soth M, Herridge M, Lapinsky S, Clark E, Garg AX, Hiremath S, Klein D, Mazer CD, Richardson RM, Wilcox ME, Friedrich JO, Burns KE, Bagshaw SM, Canadian Critical CareTrials G (2015) Comparison of standard and accelerated initiation of renal replacement therapy in acute kidney injury. Kidney Int 88:897–904

    Article  CAS  PubMed  Google Scholar 

  15. Zarbock A, Kellum JA, Schmidt C, Van Aken H, Wempe C, Pavenstadt H, Boanta A, Gerss J, Meersch M (2016) Effect of early vs delayed initiation of renal replacement therapy on mortality in critically ill patients with acute kidney injury: the ELAIN randomized clinical trial. JAMA 315:2190–2199

    Article  CAS  PubMed  Google Scholar 

  16. Meersch M, Schmidt C, Hoffmeier A, Van Aken H, Wempe C, Gerss J, Zarbock A (2017) Prevention of cardiac surgery-associated AKI by implementing the KDIGO guidelines in high risk patients identified by biomarkers: the PrevAKI randomized controlled trial. Intensive Care Med. doi:10.1007/s00134-016-4670-3

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Renal Division, Ghent University Hospital, Ghent, Belgium

    Jill Vanmassenhove

  2. Academic Teaching Hospital Braunschweig, Medical Clinic V Nephrology, Hypertension and Blood Purification, Brunswick, Germany

    Jan T. Kielstein

  3. Department of Critical Care and Nephrology, King’s College London, Guy’s and St Thomas’ Foundation Hospital, London, UK

    Marlies Ostermann

Authors
  1. Jill Vanmassenhove
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jan T. Kielstein
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Marlies Ostermann
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jill Vanmassenhove.

Ethics declarations

Conflicts of interest

The authors declare that there is no conflict of interest.

Additional information

For contrasting viewpoints, please go to doi:10.1007/s00134-017-4763-7 and doi:10.1007/s00134-017-4792-2.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Vanmassenhove, J., Kielstein, J.T. & Ostermann, M. Have renal biomarkers failed in acute kidney injury? Yes. Intensive Care Med 43, 883–886 (2017). https://doi.org/10.1007/s00134-017-4759-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00134-017-4759-3

Keywords

Search

Navigation