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This work was supported by a Japan Society for the Promotion of Science (JSPS) KAKENHI Grant (Number JP 16K09541).
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A response to these comments is available at doi:10.1007/s00134-016-4545-7.
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Yamaga, S., Ohshimo, S. & Shime, N. Is transpulmonary pressure-guided PEEP titration really optimal?. Intensive Care Med 42, 1845–1846 (2016). https://doi.org/10.1007/s00134-016-4516-z
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DOI: https://doi.org/10.1007/s00134-016-4516-z