References
Caironi P, Tognoni G, Masson S, Fumagalli R, Pesenti A, Romero M et al (2014) Albumin replacement in patients with severe sepsis or septic shock. N Engl J Med 370:1412–1421
Asfar P, Meziani F, Hamel JF, Grelon F, Megarbane B, Anguel N et al (2014) High versus low blood-pressure target in patients with septic shock. N Engl J Med 370:1583–1593
Holst LB, Haase N, Wetterslev J, Wernerman J, Guttormsen AB, Karlsson S et al (2014) Lower versus higher hemoglobin threshold for transfusion in septic shock. N Engl J Med 371:1381–1391
Yealy DM, Kellum JA, Huang DT, Barnato AE, Weissfeld LA, Pike F et al (2014) A randomized trial of protocol-based care for early septic shock. N Engl J Med 370:1683–1693
The ARISE Investigators and the ANZICS Clinical Trials Group (2014) Goal-directed resuscitation for patients with early septic shock. N Engl J Med 371:1496–1506
Conflicts of interest
LG reports grant support from the Italian Medicines Agency (AIFA, Agenzia Italiana del Farmaco) while conducting the ALBIOS study as well as speaker's fees from Grifols, Kedrion and Baxter and Advisory Board honoraria from Grifols outside the submitted work. VMR reports consultancies for MAQUET and a grant for the FARON_FPCLI001 clinical study with FP-1201 in acute lung injuries outside the submitted work. AP reports grant support from the Italian Medicines Agency (AIFA, Agenzia Italiana del Farmaco) while conducting the ALBIOS study, grant support from Chiesi Farmaceutici, consultancies for Maquet and Novalung, and fees for mechanical ventilation courses from Draeger outside the submitted work. The authors state that the subject discussed in the submitted manuscript was not dependent on financial support.
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Gattinoni, L., Ranieri, V.M. & Pesenti, A. Sepsis: needs for defining severity. Intensive Care Med 41, 551–552 (2015). https://doi.org/10.1007/s00134-014-3598-8
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DOI: https://doi.org/10.1007/s00134-014-3598-8