ICU admission characteristics and mortality rates among elderly and very elderly patients
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- Fuchs, L., Chronaki, C.E., Park, S. et al. Intensive Care Med (2012) 38: 1654. doi:10.1007/s00134-012-2629-6
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The effect of advanced age per se versus severity of chronic and acute diseases on the short- and long-term survival of older patients admitted to the intensive care unit (ICU) remains unclear.
Intensive care unit admissions to the surgical ICU and medical ICU of patients older than 65 years were analyzed. Patients were divided into three age groups: 65–74, 75–84, and 85 and above. The primary endpoints were 28-day and 1-year mortality.
The analysis focused on 7,265 patients above the age of 65, representing 45.7 % of the total ICU population. From the first to third age group there was increased prevalence of heart failure (25.9–40.3 %), cardiac arrhythmia (24.6–43.5 %), and valvular heart disease (7.5–15.8 %). There was reduced prevalence of diabetes complications (7.5–2.4 %), alcohol abuse (4.1–0.6 %), chronic obstructive pulmonary disease (COPD) (24.4–17.4 %), and liver failure (5.0–1.0 %). Logistic regression analysis adjusted for gender, sequential organ failure assessment, do not resuscitate, and Elixhauser score found that patients from the second and third age group had odds ratios of 1.38 [95 % confidence interval (CI) 1.19–1.59] and 1.53 (95 % CI 1.29–1.81) for 28-day mortality as compared with the first age group. Cox regression analysis for 1-year mortality in all populations and in 28-day survivors showed the same trend.
The proportion of elderly patients from the total ICU population is high. With advancing age, the proportion of various preexisting comorbidities and the primary reason for ICU admission change. Advanced age should be regarded as a significant independent risk factor for mortality, especially for ICU patients older than 75.
KeywordsElderlyOutcomesCritical careLong-term mortality
As the proportion of the elderly in the general population grows, the number of elderly patients being admitted to the intensive care unit (ICU) is also increasing [1–4]. The proportion of patients older than 80 years out of total ICU admissions in various developed countries has been estimated as being between 7 and 25 % and growing [5–9]. A recent analysis in Australia and New Zealand found an annual increase of 5.6 % in the number of patients over 85 years. This trend potentially translates to a 72.4 % increase in demand for ICU bed-days by 2015 .
The role of advanced age as opposed to severity of chronic and acute diseases in the short- and long-term survival of older patients admitted to the ICU remains unclear [4, 9–11]. Some studies have concluded that age is not predictive of poor prognosis for ICU patients, and that severity of illness and premorbid functional status primarily determine patient outcome [5, 7–12]. Moreover, the incremental mortality risk associated with age has not been defined in the population over 65 years.
Intensive care unit is an expensive and scarce resource. In the face of growing demand, pragmatic decisions regarding appropriate levels of care may become necessary. The results of this study will inform discussions with patients and families regarding appropriate goals of care. Characterization of the growing population of elderly patients being admitted to the ICU is vital for these discussions.
This study seeks to evaluate the association between the demographic and clinical characteristics of patients over the age of 65 and their 28-day and 1-year mortality.
Patients and methods
Assembly of the cohort
The multiparameter intelligent monitoring of intensive care (MIMIC-II) project  was approved by the institutional review boards of the Massachusetts Institute of Technology and Beth Israel Deaconess Medical Center (BIDMC) and granted a waiver of informed consent. The MIMIC-II database is maintained by researchers at the Harvard-MIT Division of Health Sciences and Technology and includes the physiologic information of patients admitted between August 2001 and 2008 to one of BIDMC’s ICUs, a large academic tertiary medical center in Boston, MA. The database contains records of demographic and clinical data as well as do not resuscitate (DNR) order on admission to the ICU. Acuity level on admission was calculated using simplified acute physiology score (SAPS-I)  and sequential organ failure assessment (SOFA) . Further clinical data added to the database included admission and death records, discharge summaries, and ICD-9 codes for primary reason of admission.
Nonplanned medical and surgical ICU admissions within the study period of ICU patients older than 65 years were initially analyzed. Cardiac vascular surgical ICU and nonsurgical cardiac ICU admissions were excluded, as only nonplanned ICU admissions were analyzed. The cohort was divided into three age groups for analysis: 65–74, 75–84, and age 85 and above.
The primary endpoints were 28-day and 1-year mortality. Data were summarized using frequency tables, summary statistics, confidence intervals, and p values, as appropriate. The preferred method of analysis for continuous variables was parametric. Nonparametric analysis methods were used only if parametric assumptions could not be satisfied, even after data transformation attempts. Parametric model assumptions were assessed using normal-plot or Shapiro–Wilk statistic for verification of normality and Levene’s test for verification of homogeneity of variances. Categorical variables were tested using Pearson’s χ2 test for contingency. Kaplan–Meier survival curves with log-rank test were built for the analysis of all-cause mortality.
The multivariate analysis for death within 28 days from admission was done using a logistic regression model. The variables were introduced into the model based on clinical and statistical significance (p value ≥0.1 on univariate analysis). The final parsimonious model included the following variables: the age groups 75–84 and over 84 versus the age group of 65–74, DNR status, SOFA  severity score at admission, and Elixhauser comorbidity score [16, 17]. The 1-year mortality analysis of all patients and the landmark analysis of the 28-day survivors were done using a Cox proportional-hazards survival regression model. For the landmark analysis the model included only patients who survived for 28 days. This type of analysis allows us to assess mortality trends in patients surviving the acute period. The variables introduced into the model included the same variables introduced into the logistic regression model.
Age trends were evaluated by fitting a locally weighted scatterplot smoothing (LOESS) curve of the adjusted mortality probability to the patient age. At each age a low-degree polynomial is fitted to a subset of the data with age values near the point at which adjusted mortality probability is estimated .
All p values reported were rounded to three decimal places. All statistical tests and/or confidence intervals, as appropriate, were performed at α = 0.05 (two-sided). The data were analyzed using SPSS 18 software.
Baseline characteristics of ICU patients, 2001–2008 (n = 7,265)
n = 2,585
n = 3,003
n = 1,677
Unit of discharge, n (%)
Male gender, n (%)
Age, years (±SD)
70.07 ± 2.88
79.87 ± 2.83
89.38 ± 3.26
Marital status, n (%)
Comorbidities, n (%)
6.17 ± 8.01
6.35 ± 7.60
6.58 ± 7.12
Congestive heart failure
Chronic renal failure
With increasing age the prevalence of some preexisting conditions increased, e.g., heart failure, cardiac arrhythmia, and valvular heart disease. However, prevalence of other conditions such as diabetes with complications, alcohol abuse, COPD, liver failure, metastatic cancer, and psychosis significantly decrease with age.
n = 2,585
n = 3,003
n = 1,677
Primary reason of admission, n (%)
Acuity score on admission
5.37 ± 3.97
5.25 ± 3.72
5.09 ± 3.53
14.09 ± 5.07
15.12 ± 4.99
15.21 ± 4.67
Intensity of care
RRT during hospitalization
228 (11.1 %)
229 (7.6 %)
80 (4.8 %)
Use of vasopressors
707 (27.4 %)
782 (26.0 %)
405 (24.2 %)
1346 (52.1 %)
1452 (48.4 %)
666 (39.7 %)
DNR at admission
Clinical outcomes in the elderly
Clinical outcomes (n = 7,265)
n = 2,585
n = 3,003
n = 1,677
LOS in days (median, IQR)
Mortality, n (%)
Logistic regression models of 28-day mortality of ICU patients
95 % CI
Age groups (vs. 65–74)
85 and up
SOFA, per point
DNR at admission
Elixhauser score, per point
Cox regression model for 1-year mortality in ICU patients
95 % CI
Age groups (vs. 65–74)
85 and over
SOFA, per point
DNR at admission
Elixhauser score, per point
In this retrospective observational study our main findings were that the elderly and very elderly constitute a major proportion of the ICU population. Among these patients, with advancing age, the proportion of various preexisting comorbidities as well as the primary reasons for ICU admission change. Mortality in the elderly population following ICU admission is high, and patient age is a significant independent risk factor for ICU mortality in a nonlinear fashion.
Proportion of elderly in the ICU
Our findings are consistent with a recent large cohort from Australia and New Zealand . In that study, among 120,123 admissions to 57 ICUs, 13 % were very elderly patients (>80 years), showing an annual ICU admission increase of 5.6 % per year. We found that 45 % of our ICU patients were over age of 65; 10.35 % were age 85 and over. Knowing the proportion of elderly patients that are being admitted to the ICU will enable policy-makers to plan for future needs. Care of elderly ICU patients should also be a focus of future comparative effectiveness research in the critically ill as premorbid conditions, the reasons for admission, and both short- and long-term outcomes differ in this population.
Risk factors for elderly ICU admission
The current study identifies a number of characteristics among elderly ICU patients of particular importance. In the older age groups, ICU admission is commonly associated with potentially preventable conditions. We found that with advanced age heart failure, cardiac arrhythmia, and valvular heart disease are more prevalent in the ICU population. To what extent these comorbidities are a reflection of advanced age with increased prevalence of chronic diseases as opposed to factors that are associated with increased risk of ICU admission is yet to be defined. On the other hand, other comorbidities significantly decreased with age: diabetes with complications, alcohol abuse, COPD, liver failure, metastatic cancer, psychosis, and drug abuse. As these diseases are rarely reversible, it is reasonable to assume that some of these comorbidities are major contributors to mortality with aging. Trauma was found to be a major reason for ICU admission and rises significantly with age (second most frequent ICU admission cause among the third age group and only fifth among the first). Primary prevention strategies should be focused on reducing trauma risk for the very elderly population (medication adjustment, home adjustment, behavioral instructions) . Gastrointestinal (GI) bleed is another example of a potentially preventable disease [20, 21].
Outcomes in the elderly
Over the age of 85, 56 % of all our patients died within 1 year from admission (36.2 % for age 65–75). This is consistent with rates from previous studies [22–23]. Wunsch et al. found that the risk is concentrated early after hospital discharge (the first 6 months) and among those who require mechanical ventilation. Roch and colleagues  demonstrated a mortality hazard ratio of 2.56 when very elderly (median age of 84) MICU survivors were compared with an age- and gender-matched cohort in the general population. None of these studies compared long-term mortality rates of different elderly age groups as we did. By comparing the outcomes of the oldest elderly group versus the youngest elderly group at 1 year from ICU admission, we show that age remains an independent mortality risk factor over time. This extends the recent Eldicus trial findings of an association between age and mortality at 28 days from ICU admission . That trial, involving numerous European ICUs , also suggests that triage decisions of elderly patients are influenced by age. Of note, the mortality rates reported in the Eldicus trial were higher than ours (27.9 vs. 20.4 %, 35.5 vs. 28 %, and 41.5 vs. 34.6 % for first to third age group, respectively). The difference in short-term mortality rate between Eldicus and our cohort highlights the impact of triage on ICU survival. In our medical center, as opposed to those in the Eldicus trial, there is no ICU refusal policy and a higher proportion of elderly patients is admitted to the ICU (10 vs. 3.3 % of total ICU patients over age 85).
Age and ICU mortality
Advanced age alone does not preclude successful ICU outcome [5, 7–12, 25, 26]. However, our data suggest that, after age 75, age becomes a significant independent risk factor for mortality. This risk is most substantial during the period of ICU admission but persists thereafter. This association holds true in the subgroup of sicker patients who received mechanical ventilation during ICU admission. We do not have a clear explanation why the association between age and mortality is stronger after age 75, except that it might be related to the average life expectancy in the USA, which is 78 [Data from World Bank, Last updated: March 30, 2012].
Boumendil et al.  have previously demonstrated that very elderly patients receive lower treatment intensity (circulatory support, renal support, and mechanical ventilation). Our findings are consistent with theirs, and in our cohort, use of RRT and mechanical ventilation decreased with advanced age even after adjustment for DNR status (OR of 0.39 and 0.64 for older than 85 years, respectively). We did not find clinically significant age-related differences in prevalence of use of vasopressors (Table 2). Thus, we cannot exclude the possibility that physician restriction of treatment contributed to the high mortality in our elderly patients.
The current work has several limitations. This is a retrospective, single-center study. We did not study the characteristics and mortality rates of the very elderly patients who were admitted to the hospital but not to the ICU, but other studies that compared elderly ICU mortality with controlled nonhospitalized or hospitalized non-ICU patients have shown significant higher mortality rates for the very elderly ICU patients [23, 24]. Our objective in this study was to evaluate the influence of age among elderly patients admitted to the ICU. We did not perform subgroup analysis based on different admission diagnosis due to the limited sample size. We also acknowledge that quality-of-life assessment post-ICU admission is an important end point which this study failed to address. Finally, the high ICU bed ratio in our medical center (14 % of total hospital beds) does not reflect the majority of hospitals in the country or around the world and might partially explain our somewhat lower mortality rates compared with the mortality rates described in the literature.
The information presented here may be useful in informing triage decisions as the proportion of the elderly population continues to increase and shortage of critical care resources is anticipated to worsen . However, mortality data alone clearly do not provide adequate information for making such decisions. What constitutes sufficient “benefit” for a particular elderly patient from an ICU admission requires broader consideration. Particularly important will be the patient’s quality of life following discharge. While this issue has been looked at in a research setting [7, 22, 28], we propose that objective measures of quality of life be obtained as part of routine care during follow-up after hospital discharge to be able to quantify the value of ICU care. Discussion and the collaborative involvement of the healthcare team and families in such decisions are also essential from an early stage in chronic diseases that commonly present in the ICU. Such collaborative decisions reflect a partnership approach that prevents unhelpful disputes about paternalism and autonomy in ethics. This accords well with good healthcare practice and an atmosphere of mutual problem solving. The need to represent the truth of the situation in such discussion is important, so decisions are made in the light of a realistic appraisal of the facts of the patient’s predicament. Where this is done with tact and consideration, with the emphasis on doing what is fitting in the context of the patient’s life and present illness, there is often little disagreement about what should happen.
Elderly and very elderly patients will continue to be a significant and increasing proportion of ICU patients. This population has demographic and clinical characteristics that should be recognized. With advancing age, the proportion of various preexisting comorbidities as well as the primary reason for ICU admission change. Primary prevention of prevalent reasons for elderly ICU admission such as falls and gastrointestinal bleeding may reduce elderly ICU admission. Mortality in this cohort is substantial, and advanced age should be regarded as a significant independent risk factor specifically for ICU patients older than 75.
Conflicts of interest
None of the authors have any financial interests or potential conflicts to disclose.