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Date: 19 Dec 2007
Acetylcysteine and enzymatic creatinine: beware of laboratory artefact!
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Sir: N-Acetylcysteine (NAC) is an antioxidant agent used as a mucolytic and to prevent acute hepatic failure following paracetamol poisoning . NAC has also been thought to prevent radiocontrast nephrotoxicity . Potential analytical interferences between NAC and creatinine measurement have been poorly studied. Tepel et al. showed no interference between their Jaffé creatinine and NAC in vitro . Enzymatic methods are more precise and specific for creatinine measurement than the classic Jaffé methods . Enzymatic assays are thus recommended. However, creatinine enzymatic assays are not free from interference, as has been described with flucytosine and high doses of dobutamine .
We have studied, in vitro, potential interferences between NAC and creatinine measurement by Jaffé and enzymatic methods. We decided to study three serum pools with creatinine concentrations around 1, 2 and 4.5 mg/dl. Each sample was analysed in duplicate before and directly after adding increasing dos...
Perrone RD, Madias NE, Levey AS (1992) Serum creatinine as an index of renal function: new insights into old concepts. Clin Chem 38:1933–1953PubMed
- Acetylcysteine and enzymatic creatinine: beware of laboratory artefact!
Intensive Care Medicine
Volume 34, Issue 5 , pp 973-974
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- 1. Department of Clinical Chemistry, CHU Sart Tilman, Liège, Belgium
- 2. Department of Medicine, Medical Intensive Care Unit, CHU Sart Tilman, Liège, Belgium
- 3. Department of Nephrology, Dialysis, and Hypertension, University of Liège, Service de Dialyse, CHU Sart Tilman, 4000, Liège, Belgium