Intensive Care Medicine

, Volume 32, Issue 7, pp 1030–1038

Cardiac response is greater for colloid than saline fluid loading after cardiac or vascular surgery

  • Joanne Verheij
  • Arthur van Lingen
  • Albertus Beishuizen
  • Herman M. T. Christiaans
  • Jan R. de Jong
  • Armand R. J. Girbes
  • Willem Wisselink
  • Jan A. Rauwerda
  • Marinus A. J. M. Huybregts
  • A. B. Johan Groeneveld
Original

DOI: 10.1007/s00134-006-0195-5

Cite this article as:
Verheij, J., van Lingen, A., Beishuizen, A. et al. Intensive Care Med (2006) 32: 1030. doi:10.1007/s00134-006-0195-5

Abstract

Objective

To study the effects on volume expansion and myocardial function of colloids or crystalloids in the treatment of hypovolaemic hypotension after cardiac and major vascular surgery.

Design and setting

A single-centre, single-blinded, randomized clinical trial at the intensive care unit of a university hospital.

Patients and methods

Patients (n = 67) were subjected to a 90-min filling pressure-guided fluid challenge with saline 0.9% or the colloids gelatin 4%, hydroxyethyl starch 6% or albumin 5%. Biochemical variables and haemodynamics (transpulmonary thermodilution) were measured.

Results

An amount of 1800 (1300–1800) ml of saline or 1600 (750–1800) ml of colloid solution (P< 0.005) was infused. Colloid osmotic pressure (COP) decreased in the saline group and increased in the colloid groups (P< 0.001). Plasma volume increased by 3.0% (–18 to 24) in the saline versus 19% (–11 to 50) in the colloid groups (P< 0.001). Cardiac index increased by median 13% (ns) in the saline group and by 22% in the colloid groups (P< 0.005). The rise in left ventricular stroke work index was greater in the colloid than in the saline groups. The different colloids were equally effective. The rise in cardiac index related to the rise in plasma volume and global end-diastolic volume, confirming plasma volume and preload augmentation by the fluid loading.

Conclusion

After cardiac or major vascular surgery, the pressure- and time-guided fluid response is dependent on the type of fluid used. Colloid fluid loading leads to a greater increase in preload-recruitable cardiac and left ventricular stroke work indices than that with saline, because of greater plasma volume expansion following an increase in plasma COP.

Keywords

Colloids- CrystalloidsCardiac contractilityCardiac compliancePreload-recruitable stroke workHypovolaemiaGlobal end-diastolic volumeFluid responsiveness

Supplementary material

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Joanne Verheij
    • 1
    • 2
  • Arthur van Lingen
    • 2
    • 3
  • Albertus Beishuizen
    • 1
    • 2
  • Herman M. T. Christiaans
    • 4
  • Jan R. de Jong
    • 4
  • Armand R. J. Girbes
    • 1
    • 2
  • Willem Wisselink
    • 5
  • Jan A. Rauwerda
    • 5
  • Marinus A. J. M. Huybregts
    • 6
  • A. B. Johan Groeneveld
    • 1
    • 2
  1. 1.Department of Intensive CareVU Medical CentreAmsterdamThe Netherlands
  2. 2.Institute for Cardiovascular ResearchVU Medical CentreAmsterdamThe Netherlands
  3. 3.Department of Nuclear MedicineVU Medical CentreAmsterdamThe Netherlands
  4. 4.Department of AnaesthesiologyVU Medical CentreAmsterdamThe Netherlands
  5. 5.Department of Vascular SurgeryVU Medical CentreAmsterdamThe Netherlands
  6. 6.Department of Cardiothoracic SurgeryVU Medical CentreAmsterdamThe Netherlands