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Effects of Barium Chloride Exposure on Hormones and Genes of the Hypothalamic–Pituitary–Gonad Axis, and Reproduction of Zebrafish (Danio rerio)

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Abstract

Adult zebrafish pairs were exposed to sub-lethal concentrations of BaCl2 for 21 days, and the effects on reproduction, sex steroid hormones, and transcription of the genes belonging to the hypothalamic–pituitary–gonad (HPG) axis were investigated. The adverse effects on performances of F1 generation were further examined with or without subsequent exposure to BaCl2. Egg production was significantly decreased, and parental exposure to BaCl2 resulted in lesser rates of hatching. In males, exposure to BaCl2 resulted in greater concentrations of E2 along with greater mRNA expression of cyp19a. The results demonstrated that BaCl2 could modulate gene transcriptions and hormone production of the HPG axis in a sex-dependent way, which could cause adverse effects on reproduction and the development of offspring.

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Acknowledgments

This study was supported by National Research Foundation of Korea (NRF; Project No. 2013R1A1A1061684).

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Authors and Affiliations

  1. Department of Environmental Health, Graduate School of Yongin University, Yongin, 17092, Republic of Korea

    Bareum Kwon, Pan-Gyi Kim & Kyunghee Ji

  2. Graduate School of Public Health, Seoul National University, Seoul, 08826, Republic of Korea

    Nayoung Ha, Joeun Jung & Kyungho Choi

  3. Department of Health, Environment and Safety, Eulji University, Gyeonggi, Seongnam, 13135, Republic of Korea

    Younglim Kho

  4. Department of Occupational and Environmental Health, Yongin University, Yongin, 17092, Republic of Korea

    Kyunghee Ji

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  1. Bareum Kwon
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  2. Nayoung Ha
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  3. Joeun Jung
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  4. Pan-Gyi Kim
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  5. Younglim Kho
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  6. Kyungho Choi
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  7. Kyunghee Ji
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Correspondence to Kyunghee Ji.

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Kwon, B., Ha, N., Jung, J. et al. Effects of Barium Chloride Exposure on Hormones and Genes of the Hypothalamic–Pituitary–Gonad Axis, and Reproduction of Zebrafish (Danio rerio). Bull Environ Contam Toxicol 96, 341–346 (2016). https://doi.org/10.1007/s00128-016-1731-9

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  • DOI: https://doi.org/10.1007/s00128-016-1731-9

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