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Lead Bone Toxicity in Growing Rats Exposed to Chronic Intermittent Hypoxia

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Abstract

Lead chronic intoxication under hypoxic conditions revealed growth retardation in growing rats and damages on femoral and mandibular bones that predispose to fractures. These findings aimed us to investigate if bone material and geometric properties, bone mass in terms of histomorphometry or antioxidant capacity are also impaired in such experimental model. Combined treatments significantly reduced hemimandible cross sectional geometry and intrinsic stiffness (−16 % and −34 %); tibia and hemimandible bone volume (−45 % and −40 %) and growth plate cartilage thickness (−19 %). These results show a previously unreported toxic effect of lead on mandible however, longer studies should be necessary to evaluate if an adaptation of bone architecture to maintain structural properties may occur and if the oxidative stress can be identified as the primary contributory agent in the pathogenesis of lead poisoning.

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Acknowledgments

The authors acknowledge the collaboration of physiology laboratory technicians Graciela M. Champin and Elsa Lingua, Department of Physiology, School of Dentistry, University of Buenos Aires. This work was supported by research grants from University of Buenos Aires (UBACyT 20020090200013).

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Authors and Affiliations

  1. Department of Physiology, University of Buenos Aires, MT Alvear 2142, 3rd. floor “A”, Buenos Aires, Argentina

    María I. Conti, Clarisa Bozzini, Ching M. Lee, Antonela R. Terrizzi & María P. Martínez

  2. Department of Histology and Embryology, Faculty of Dentistry, University of Buenos Aires, Buenos Aires, Argentina

    Patricia M. Mandalunis

  3. Department of Physics, University of Buenos Aires, Buenos Aires, Argentina

    Graciela B. Facorro & Lidia L. Piehl

  4. Department of Toxicology and Legal Chemistry, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina

    Adriana E. Piñeiro

Authors
  1. María I. Conti
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  2. Clarisa Bozzini
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  3. Graciela B. Facorro
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  4. Ching M. Lee
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  5. Patricia M. Mandalunis
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  6. Lidia L. Piehl
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  7. Adriana E. Piñeiro
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  8. Antonela R. Terrizzi
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  9. María P. Martínez
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Corresponding author

Correspondence to María I. Conti.

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Conti, M.I., Bozzini, C., Facorro, G.B. et al. Lead Bone Toxicity in Growing Rats Exposed to Chronic Intermittent Hypoxia. Bull Environ Contam Toxicol 89, 693–698 (2012). https://doi.org/10.1007/s00128-012-0753-1

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  • DOI: https://doi.org/10.1007/s00128-012-0753-1

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