Longitudinal changes in pancreatic and adipocyte hormones following Roux-en-Y gastric bypass surgery
Bariatric surgery is an effective treatment for severe obesity, as in addition to dramatic weight loss, co-morbidities such as type 2 diabetes are frequently resolved. Although altered gastrointestinal peptide hormone secretion and its relationship with post-surgical improvements in insulin sensitivity has been studied, much less is known about long-term changes in pancreatic and adipose tissue-derived hormones. Our objective was to conduct a comprehensive longitudinal investigation of the endocrine changes following Roux-en-Y gastric bypass surgery (RYGBP), focusing on pancreatic and adipocyte hormones and systemic markers of inflammation.
Nineteen severely obese women (BMI 45.6 ± 1.6 kg/m2) were studied prior to RYGBP, and at 1, 3, 6, and 12 months after RYGBP. Body composition was assessed before surgery and at 1 and 12 months.
Pre-surgical adiposity was correlated with circulating adipocyte hormones (leptin, visfatin) and inflammatory molecules (IL-6, high sensitivity C-reactive protein [hsCRP], monocyte chemoattractant protein-1). As expected, RYGBP reduced fat mass and fasting insulin and glucose concentrations. In addition, reductions of fasting pancreatic polypeptide (PP) and glucagon concentrations were observed at 1 and 3 months, respectively. In the 12 months following RYGBP, concentrations of most adipocyte hormones (leptin, acylation-stimulating hormone and visfatin, but not retinol-binding hormone-4) and inflammatory molecules (IL-6, hsCRP and soluble intracellular adhesion molecule-1) were significantly reduced. Reductions of insulin resistance (measured by homeostasis model assessment of insulin resistance) were independently associated with changes of glucagon, visfatin and PP. Pre-surgical HMW adiponectin concentrations independently predicted losses of body weight and fat mass.
These results suggest that pancreatic and adipocyte hormones may contribute to the long-term resolution of insulin resistance after RYGBP.
- Longitudinal changes in pancreatic and adipocyte hormones following Roux-en-Y gastric bypass surgery
Volume 51, Issue 10 , pp 1901-1911
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Clinical science
- Gastro-entero pancreatic factors
- Insulin sensitivity and resistance
- Other hormones
- Other islet cells/hormones
- Weight regulation and obesity
- Industry Sectors
- Author Affiliations
- 1. Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, One Shields Ave, Davis, CA, 95616-5270, USA
- 2. Department of Nutrition, College of Agricultural and Environmental Sciences, University of California, Davis, CA, USA
- 3. Department of Surgery, School of Medicine, University of California, Davis, CA, USA
- 4. United States Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research Center, Davis, CA, USA
- 5. Department of Surgery, Oregon Health & Science University, Portland, OR, USA