Theoretical and Applied Genetics

, Volume 126, Issue 6, pp 1419-1430

First online:

Family-based association mapping in crop species

  • Baohong GuoAffiliated withSyngenta Biotechnology, Inc Email author 
  • , Daolong WangAffiliated withSyngenta Biotechnology, Inc
  • , Zhigang GuoAffiliated withSyngenta Biotechnology, Inc
  • , William D. BeavisAffiliated withIowa State University Email author 

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Identification of allelic variants associated with complex traits provides molecular genetic information associated with variability upon which both artificial and natural selections are based. Family-based association mapping (FBAM) takes advantage of linkage disequilibrium among segregating progeny within crosses and among parents to provide greater power than association mapping and greater resolution than linkage mapping. Herein, we discuss the potential adaption of human family-based association tests and quantitative transmission disequilibrium tests for use in crop species. The rapid technological advancement of next generation sequencing will enable sequencing of all parents in a planned crossing design, with subsequent imputation of genotypes for all segregating progeny. These technical advancements are easily adapted to mating designs routinely used by plant breeders. Thus, FBAM has the potential to be widely adopted for discovering alleles, common and rare, underlying complex traits in crop species.