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Techniken zur Leberfettquantifizierung bei der Risikostratifikation von Diabetikern

Techniques for quantification of liver fat in risk stratification of diabetics

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Zusammenfassung

Klinisches/methodisches Problem

Die Fettleber scheint einen unmittelbaren Einfluss auf die Pathophysiologie des Diabetes mellitus Typ 2 zu besitzen. Zur Detektion und Quantifizierung des Leberfetts werden in der klinischen Diagnostik akkurate Verfahren gebraucht.

Radiologische Standardverfahren

Ein einfaches Verfahren ist die Chemical-shift-kodierte Magnetresonanztomographie (MRT).

Methodische Innovationen

Eine suffiziente Quantifizierung von Leberfett mithilfe der Chemical-shift-kodierten MRT erfordert eine Berücksichtigung von Störvariablen, wie den T2*-Zerfall, den T1-Wiederaufbau und die multispektrale Komplexität von Fett.

Leistungsfähigkeit

Eine Korrektur aller Störvariablen wird als Proton-density-Fettfraktion bezeichnet. Diese liefert unabhängig von der verwendeten Einstellung und Hardware reproduzierbare Ergebnisse.

Bewertung

Die korrigierte Proton-density-Fettfraktion ist ein akkurater Biomarker zur Quantifizierung von Leberfett.

Empfehlung für die Praxis

Die akkurate und reproduzierbare Quantifizierung von Leberfett in der MRT erfordert eine Berechnung der Proton-density-Fettfraktion.

Abstract

Clinical/methodical issue

Fatty liver disease plays an important role in the development of type 2 diabetes. Accurate techniques for detection and quantification of liver fat are essential for clinical diagnostics.

Standard radiological methods

Chemical shift-encoded magnetic resonance imaging (MRI) is a simple approach to quantify liver fat content.

Methodical innovations

Liver fat quantification using chemical shift-encoded MRI is influenced by several bias factors, such as T2* decay, T1 recovery and the multispectral complexity of fat.

Performance

The confounder corrected proton density fat fraction is a simple approach to quantify liver fat with comparable results independent of the software and hardware used.

Achievements

The proton density fat fraction is an accurate biomarker for assessment of liver fat.

Practical recommendations

An accurate and reproducible quantification of liver fat using chemical shift-encoded MRI requires a calculation of the proton density fat fraction.

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Einhaltung ethischer Richtlinien

Interessenkonflikt. J.-P. Kühn. M.C. Spoerl, C. Mahlke, K. Hegenscheid geben an, dass kein Interessenkonflikt besteht. Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.

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Authors and Affiliations

  1. Abteilung Experimentelle Radiologie, Institut für Diagnostische Radiologie und Neuroradiologie, Universitätsmedizin Greifswald, Sauerbruchstr. 1, 17489, Greifswald, Deutschland

    J.-P. Kühn, M.C. Spoerl, C. Mahlke & K. Hegenscheid

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  1. J.-P. Kühn
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  2. M.C. Spoerl
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  3. C. Mahlke
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Correspondence to J.-P. Kühn.

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Kühn, JP., Spoerl, M., Mahlke, C. et al. Techniken zur Leberfettquantifizierung bei der Risikostratifikation von Diabetikern. Radiologe 55, 308–313 (2015). https://doi.org/10.1007/s00117-014-2720-9

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  • DOI: https://doi.org/10.1007/s00117-014-2720-9

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