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Innovative Diagnostik für die pädiatrische Infektiologie

Innovative diagnostics for pediatric infections

  • Leitthema
  • Published:
Monatsschrift Kinderheilkunde Aims and scope Submit manuscript

Zusammenfassung

Hintergrund

Innerhalb der letzten Jahre hat die Bedeutung neuer Biomarker in der Infektionsdiagnostik zugenommen. Die Nützlichkeit dieser neuen diagnostischen Tools wird intensiv diskutiert.

Material und Methoden

In dieser Übersicht wird die wissenschaftliche Wertigkeit neuer Biomarker für wichtige Infektionskrankheiten dargestellt und diskutiert.

Ergebnisse

Unter den neuen Biomarkern ist die wissenschaftliche Datenlage für Prokalzitonin (PCT) mit am besten. Der routinemäßige Einsatz v. a. bei Neugeborenensepsis und an Meningitis erkrankten Kindern über 3 Monaten erscheint vielversprechend.

Schlussfolgerungen

Neue Biomarker können die Diagnostik von Infektionskrankheiten bei Kindern verbessern. Diese sollten jedoch gezielt eingesetzt werden, da der unkritische Einsatz mit erheblichen Kosten einhergehen kann.

Abstract

Background

In recent years the importance of new biomarkers in the diagnostics of infections has steadily grown; however, the usefulness of these new diagnostic tools is still under intensive debate.

Material and methods

In this review the scientific evidence for the usefulness of new biomarkers in the diagnostics of important infectious diseases will be presented and discussed.

Results

Among the new biomarkers most scientific data exist for procalcitonin (PCT). The routine use in diagnosing neonatal sepsis and meningitis in children over 3 months of age seems to be promising.

Conclusion

New biomarkers can potentially optimize the diagnostics of infections in children. Nevertheless, a targeted use should be pursued, because the uncritical use can be associated with significant costs.

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Einhaltung ethischer Richtlinien

Interessenkonflikt. T. Tenenbaum und J. Pöschl haben Honorare für Vorträge von der Fa. Thermo Fisher erhalten. Der Inhalt dieser Übersichtsarbeit vertritt aber die unabhängige Meinung der Autoren. Der Beitrag enthält keine Studien an Menschen oder Tieren.

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Authors and Affiliations

  1. Pädiatrische Infektiologie und Pneumologie, Universitätsklinik für Kinder- und Jugendmedizin Mannheim, Theodor-Kutzer Ufer 1–3, 68167, Mannheim, Deutschland

    T. Tenenbaum

  2. Zentrum für Kinder- und Jugendmedizin, Klinik für Neonatologie, Angelika-Lautenschläger-Klinik, Heidelberg, Deutschland

    J. Pöschl

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  1. T. Tenenbaum
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Correspondence to T. Tenenbaum.

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Tenenbaum, T., Pöschl, J. Innovative Diagnostik für die pädiatrische Infektiologie. Monatsschr Kinderheilkd 162, 687–692 (2014). https://doi.org/10.1007/s00112-014-3100-2

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  • DOI: https://doi.org/10.1007/s00112-014-3100-2

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