Journal of Molecular Medicine

, Volume 90, Issue 5, pp 509–522

Evolutionary molecular medicine

  • Randolph M. Nesse
  • Detlev Ganten
  • T. Ryan Gregory
  • Gilbert S. Omenn

DOI: 10.1007/s00109-012-0889-9

Cite this article as:
Nesse, R.M., Ganten, D., Gregory, T.R. et al. J Mol Med (2012) 90: 509. doi:10.1007/s00109-012-0889-9


Evolution has long provided a foundation for population genetics, but some major advances in evolutionary biology from the twentieth century that provide foundations for evolutionary medicine are only now being applied in molecular medicine. They include the need for both proximate and evolutionary explanations, kin selection, evolutionary models for cooperation, competition between alleles, co-evolution, and new strategies for tracing phylogenies and identifying signals of selection. Recent advances in genomics are transforming evolutionary biology in ways that create even more opportunities for progress at its interfaces with genetics, medicine, and public health. This article reviews 15 evolutionary principles and their applications in molecular medicine in hopes that readers will use them and related principles to speed the development of evolutionary molecular medicine.


EvolutionBiologyGeneticsDarwinian medicineEvolutionary medicineEvolutionary molecular medicine

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Randolph M. Nesse
    • 1
  • Detlev Ganten
    • 2
  • T. Ryan Gregory
    • 3
  • Gilbert S. Omenn
    • 4
  1. 1.Detrainments of Psychiatry and PsychologyThe University of MichiganAnn ArborUSA
  2. 2.Charite-Universitätsmedizin BerlinMax Delbrück Center for Molecular Medicine (MDC)BerlinGermany
  3. 3.Department of Integrative BiologyUniversity of GuelphGuelphCanada
  4. 4.Center for Computational Medicine and BioinformaticsUniversity of MichiganAnn ArborUSA