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Morbus Galli-Galli

Klinische und histopathologische Untersuchung anhand einer Fallserie von 18 Patienten

Galli-Galli disease

Clinical and histopathological investigation using a case series of 18 patients

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Zusammenfassung

Die seltene Genodermatose M. Galli-Galli gehört zum Spektrum der retikulären Pigmentdermatosen und wird aufgrund der charakteristischen klinischen und histologischen Befunde als akantholytische Variante des M. Dowling-Degos bezeichnet. Im Rahmen dieser Fallserie wird anhand der klinischen und histopathologischen Evaluation von 18 Patienten der M. Galli-Galli näher charakterisiert und die Erkrankung anhand der aktuellen Literatur diskutiert. Darüber hinaus wird eine Unterscheidung in 2 klinische Subtypen vorgenommen und eine Genotyp-Phänotyp-Beziehung mit Mutationen im Keratin-5 (KRT5)-Gen hergestellt.

Abstract

Galli-Galli disease, a rare genodermatosis belonging to the spectrum of reticulate pigment dermatoses, is classified as an acantholytic variant of Dowling-Degos disease on the basis of its characteristic clinical and histological findings. In the context of this case series, Galli-Galli disease is characterized in detail based on the clinical and histopathological evaluation of 18 patients. The disease pattern is discussed in view of the current literature. In addition, a classification into two clinical subtypes is made and a genotype/phenotype correlation with mutations in the keratin 5 (KRT5) gene is established.

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Danksagung

Wir danken den niedergelassenen dermatologischen Kollegen für ihre Kooperation. R.C.B. hat eine Heisenberg-Professur der Deutschen Forschungsgemeinschaft inne.

Interessenkonflikt

Der korrespondierende Autor gibt an, dass kein Interessenkonflikt besteht.

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Authors and Affiliations

  1. Hautklinik, Universitätsklinikum Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Deutschland

    S. Hanneken, S. Eigelshoven, T. Ruzicka & R. Kruse

  2. Dermatopathologie Bodensee, Friedrichshafen, Deutschland

    A. Rütten

  3. Klinik und Poliklinik für Dermatologie und Allergologie, Ludwig-Maximilians-Universität, München, Deutschland

    M. Braun-Falco & T. Ruzicka

  4. Institut für Humangenetik, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Deutschland

    S.M. Pasternack, M.M. Nöthen & R.C. Betz

  5. Department of Genomics, Forschungszentrum Life & Brain, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Deutschland

    M.M. Nöthen

Authors
  1. S. Hanneken
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  2. A. Rütten
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  3. S. Eigelshoven
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  4. M. Braun-Falco
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  5. S.M. Pasternack
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  6. T. Ruzicka
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  7. M.M. Nöthen
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  8. R.C. Betz
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  9. R. Kruse
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Corresponding author

Correspondence to S. Hanneken.

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Hanneken, S., Rütten, A., Eigelshoven, S. et al. Morbus Galli-Galli. Hautarzt 62, 842–851 (2011). https://doi.org/10.1007/s00105-011-2222-x

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  • DOI: https://doi.org/10.1007/s00105-011-2222-x

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