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Internationale Leitlinien der Surviving Sepsis Campaign

Update 2016

International guidelines from the Surviving Sepsis Campaign

2016 update

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Zusammenfassung

Nach vier Jahren wurde ein neues Update der internationalen Leitlinien zur Therapie der Sepsis durch die Surviving Sepsis Campaign (SSC) veröffentlicht. Die Leitlinien wurden vollkommen neu strukturiert und umfassend bearbeitet. Sepsisspezifische Therapiemaßnahmen sowie allgemeine intensivmedizinische Maßnahmen bei Sepsis sind detailliert dargestellt. Schwerpunkte der Neufassung sind die initiale Stabilisierung und die antiinfektive Therapie. Im vorliegenden Beitrag sollen die wichtigsten Neuerungen adressiert werden und so zur Lektüre der Leitlinien anregen.

Abstract

An update to the international guidelines for sepsis therapy was published by the Surviving Sepsis Campaign (SSC) in March 2017. The guidelines have been completely restructured and comprehensively deal with new evidence. The guidelines discuss sepsis-specific therapeutic measures and provide detailed recommendations on general intensive care measures for sepsis. This article summarizes the most important amendments and suggests delving deeper into the guidelines.

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Literatur

  1. Rhodes A, Evans LE, Alhazzani W, Levy MM, Antonelli M, Ferrer R et al (2017) Surviving sepsis campaign: International guidelines for management of sepsis and septic shock: 2016. Crit Care Med 45(3):486–552

    Article  PubMed  Google Scholar 

  2. Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M et al (2016) The third international consensus definitions for sepsis and septic shock (sepsis-3). JAMA 315(8):801–810

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Kunz R, Burnand B, Schunemann HJ (2008) The GRADE System. An international approach to standardize the graduation of evidence and recommendations in guidelines. Internist 49(6):673–680

    Article  CAS  PubMed  Google Scholar 

  4. Dellinger RP, Schorr CA, Levy MM (2017) A users’ guide to the 2016 Surviving Sepsis Guidelines. Intensive Care Med 43(3):299–303

    Article  PubMed  Google Scholar 

  5. Angus DC, Barnato AE, Bell D, Bellomo R, Chong CR, Coats TJ et al (2015) A systematic review and meta-analysis of early goal-directed therapy for septic shock: The ARISE, ProCESS and ProMISe Investigators. Intensive Care Med 41(9):1549–1560

    Article  CAS  PubMed  Google Scholar 

  6. Investigators A, Group ACT, Peake SL, Delaney A, Bailey M, Bellomo R et al (2014) Goal-directed resuscitation for patients with early septic shock. N Engl J Med 371(16):1496–1506

    Article  Google Scholar 

  7. Mouncey PR, Osborn TM, Power GS, Harrison DA, Sadique MZ, Grieve RD et al (2015) Trial of early, goal-directed resuscitation for septic shock. N Engl J Med 372(14):1301–1311

    Article  CAS  PubMed  Google Scholar 

  8. Investigators TP (2014) A randomized trial of protocol-based care for early septic shock. N Engl J Med 370(18):1683–1693

    Article  Google Scholar 

  9. Asfar P, Meziani F, Hamel J‑F, Grelon F, Megarbane B, Anguel N et al (2014) High versus low blood-pressure target in patients with septic shock. N Engl J Med 370(17):1583–1593

    Article  CAS  PubMed  Google Scholar 

  10. Holst LB, Haase N, Wetterslev J, Wernerman J, Aneman A, Guttormsen AB et al (2013) Transfusion requirements in septic shock (TRISS) trial – comparing the effects and safety of liberal versus restrictive red blood cell transfusion in septic shock patients in the ICU: protocol for a randomised controlled trial. Trials 14:150

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Damiani E, Donati A, Serafini G, Rinaldi L, Adrario E, Pelaia P et al (2015) Effect of performance improvement programs on compliance with sepsis bundles and mortality: a systematic review and meta-analysis of observational studies. PLOS ONE 10(5):e0125827

    Article  PubMed  PubMed Central  Google Scholar 

  12. Scheer CS, Fuchs C, Kuhn SO, Vollmer M, Rehberg S, Friesecke S et al (2017) Quality improvement initiative for severe sepsis and septic shock reduces 90-day mortality: A 7.5-year observational study. Crit Care Med 45(2):241–252

    Article  PubMed  Google Scholar 

  13. Bloos F, Thomas-Ruddel D, Ruddel H, Engel C, Schwarzkopf D, Marshall JC et al (2014) Impact of compliance with infection management guidelines on outcome in patients with severe sepsis: A prospective observational multi-center study. Crit Care 18(2):R42

    Article  PubMed  PubMed Central  Google Scholar 

  14. Azuhata T, Kinoshita K, Kawano D, Komatsu T, Sakurai A, Chiba Y et al (2014) Time from admission to initiation of surgery for source control is a critical determinant of survival in patients with gastrointestinal perforation with associated septic shock. Crit Care 18(3):R87

    Article  PubMed  PubMed Central  Google Scholar 

  15. ARDSNetwork (2000) Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N Engl J Med 342(18):1301–1308

    Article  Google Scholar 

  16. Amato MB, Meade MO, Slutsky AS, Brochard L, Costa EL, Schoenfeld DA et al (2015) Driving pressure and survival in the acute respiratory distress syndrome. N Engl J Med 372(8):747–755

    Article  CAS  PubMed  Google Scholar 

  17. Ferguson ND, Cook DJ, Guyatt GH, Mehta S, Hand L, Austin P et al (2013) High-frequency oscillation in early acute respiratory distress syndrome. N Engl J Med 368(9):795–805

    Article  CAS  PubMed  Google Scholar 

  18. Frat JP, Thille AW, Mercat A, Girault C, Ragot S, Perbet S et al (2015) High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure. N Engl J Med 372(23):2185–2196

    Article  CAS  PubMed  Google Scholar 

  19. Bloos F, Trips E, Nierhaus A, Briegel J, Heyland DK, Jaschinski U et al (2016) Effect of sodium selenite administration and Procalcitonin-guided therapy on mortality in patients with severe sepsis or septic shock: A randomized clinical trial. JAMA Intern Med 176(9):1266–1276

    Article  PubMed  Google Scholar 

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Correspondence to J. Briegel.

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Interessenkonflikt

J. Briegel und P. Möhnle geben an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren.

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Briegel, J., Möhnle, P. Internationale Leitlinien der Surviving Sepsis Campaign. Anaesthesist 66, 530–538 (2017). https://doi.org/10.1007/s00101-017-0299-z

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  • DOI: https://doi.org/10.1007/s00101-017-0299-z

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