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Neuroprotektion durch Edelgase

Neue Entwicklungen und Erkenntnisse

Neuroprotection by noble gases

New developments and insights

  • Klinische Pharmakologie
  • Published:
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Zusammenfassung

Edelgase sind chemisch inerte Elemente, die z. T. biologische Aktivität haben. Besonders neuroprotektive Eigenschaften sind für Xenon, Argon und auch Helium experimentell gut belegt. Die zugrunde liegenden Mechanismen hierfür sind noch nicht vollständig aufgeklärt. Neben der Beeinflussung von neuronalen Ionenkanälen und zellulären Signaltransduktionskaskaden sowie antiapoptotischen Effekten scheint auch die Modulation der Neuroinflammation eine entscheidende Rolle zu spielen. Die vorliegende Übersicht beleuchtet den aktuellen Stand der Forschung zur Neuroprotektion durch Edelgase mit einem Fokus auf Interaktionen mit dem neuronal-glialen Netzwerk sowie der Neuroinflammation und gibt einen Ausblick auf mögliche klinische Anwendungen.

Abstract

Noble gases are chemically inert elements, some of which exert biological activity. Experimental neuroprotection in particular has been widely shown for xenon, argon and helium. The underlying mechanisms of action are not yet fully understood. Besides an interference with neuronal ion-gated channels and cellular signaling pathways as well as anti-apoptotic effects, the modulation of neuroinflammation seems to play a crucial role. This review presents the current knowledge on neuroprotection by noble gases with a focus on interactions with the neuronal-glial network and neuroinflammation and the perspectives on clinical applications.

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Authors and Affiliations

  1. Klinik für Anästhesiologie, Universitätsklinikum Aachen, RWTH Aachen, Pauwelsstr. 30, 52074, Aachen, Deutschland

    A. V. Fahlenkamp, R. Rossaint Prof. Dr. & M. Coburn Prof. Dr.

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  1. A. V. Fahlenkamp
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  2. R. Rossaint Prof. Dr.
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  3. M. Coburn Prof. Dr.
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Correspondence to A. V. Fahlenkamp.

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Interessenkonflikt

A.V. Fahlenkamp hat eine Reisekostenübernahme zu einem Studienprüfer-Treffen von Air Liquide Sante International, einem Unternehmen das medizinische Gase wie Xenon und Argon vertreibt, erhalten. R. Rossaint und M. Coburn haben Beratungstätigkeiten vergütet, Studienunterstützungen sowie Honorare für Vorträge von Air Liquide Sante International bekommen.

Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.

Additional information

A.V. Fahlenkamp ist Mitglied des „Wissenschaftlichen Arbeitskreises Wissenschaftlicher Nachwuchs (WAKWiN)“ der Deutschen Gesellschaft für Anästhesiologie und Intensivmedizin e. V. (DGAI).

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Fahlenkamp, A., Rossaint, R. & Coburn, M. Neuroprotektion durch Edelgase. Anaesthesist 64, 855–858 (2015). https://doi.org/10.1007/s00101-015-0079-6

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